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Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia–Reperfusion Injury

Background: Cardiac autophagic flux is impaired during myocardial ischemia/reperfusion (MI/R). Impaired autophagic flux may exacerbate MI/R injury. Charged multivesicular body protein 2B (CHMP2B) is a subunit of the endosomal sorting complex required for transport (ESCRT-III) complex that is require...

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Detalles Bibliográficos
Autores principales:	Li, Tian, Yin, Yue, Mu, Nan, Wang, Yishi, Liu, Manling, Chen, Mai, Jiang, Wenhua, Yu, Lu, Li, Yan, Ma, Heng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892907/ https://www.ncbi.nlm.nih.gov/pubmed/33614629 http://dx.doi.org/10.3389/fcell.2020.621509

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