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Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults
The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring of sedentary patterns and PA was conducted i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892961/ https://www.ncbi.nlm.nih.gov/pubmed/33613317 http://dx.doi.org/10.3389/fphys.2021.625950 |
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author | Bergens, Oscar Nilsson, Andreas Papaioannou, Konstantinos-Georgios Kadi, Fawzi |
author_facet | Bergens, Oscar Nilsson, Andreas Papaioannou, Konstantinos-Georgios Kadi, Fawzi |
author_sort | Bergens, Oscar |
collection | PubMed |
description | The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring of sedentary patterns and PA was conducted in a population of older men (n = 83; age: 67.4 ± 1.5; height: 178.7 ± 6.6 cm; weight: 80.9 ± 10.6 kg) and women (n = 146; age: 67.4 ± 1.6; height: 164.2 ± 6.1 cm; weight: 64.6 ± 10.1 kg) aged 65–70. Blood samples were collected for the assessment of the inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, IL-18, and monocyte chemoattractant protein-1 (MCP-1). Data were analyzed using multiple linear regression models. Total and bouts of ≥10 min of sedentary time were inversely associated with the anti-inflammatory marker IL-10 in older men (accumulated sedentary time: β = −0.116; bouts: β = −0.099; all p < 0.05). Associations were independent of moderate-to-vigorous physical activity (MVPA) and total PA volume. In women, total and bouts of ≥10 min of sedentary time were detrimentally associated with the pro-inflammatory marker fibrinogen (accumulated sedentary time: β = −0.130; bouts: β = −0.085; all p < 0.05). Associations remained between accumulated sedentary time and fibrinogen when adjusting for MVPA and total PA volume. This study highlights sex-specific routes by which sedentary patterns impact on pro- and anti-inflammatory biomarkers in older adults. The findings support efforts to promote accumulation of time spent in PA at the expense of time in sedentary pursuits on low-grade inflammation in older men and women. |
format | Online Article Text |
id | pubmed-7892961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78929612021-02-20 Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults Bergens, Oscar Nilsson, Andreas Papaioannou, Konstantinos-Georgios Kadi, Fawzi Front Physiol Physiology The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring of sedentary patterns and PA was conducted in a population of older men (n = 83; age: 67.4 ± 1.5; height: 178.7 ± 6.6 cm; weight: 80.9 ± 10.6 kg) and women (n = 146; age: 67.4 ± 1.6; height: 164.2 ± 6.1 cm; weight: 64.6 ± 10.1 kg) aged 65–70. Blood samples were collected for the assessment of the inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, IL-18, and monocyte chemoattractant protein-1 (MCP-1). Data were analyzed using multiple linear regression models. Total and bouts of ≥10 min of sedentary time were inversely associated with the anti-inflammatory marker IL-10 in older men (accumulated sedentary time: β = −0.116; bouts: β = −0.099; all p < 0.05). Associations were independent of moderate-to-vigorous physical activity (MVPA) and total PA volume. In women, total and bouts of ≥10 min of sedentary time were detrimentally associated with the pro-inflammatory marker fibrinogen (accumulated sedentary time: β = −0.130; bouts: β = −0.085; all p < 0.05). Associations remained between accumulated sedentary time and fibrinogen when adjusting for MVPA and total PA volume. This study highlights sex-specific routes by which sedentary patterns impact on pro- and anti-inflammatory biomarkers in older adults. The findings support efforts to promote accumulation of time spent in PA at the expense of time in sedentary pursuits on low-grade inflammation in older men and women. Frontiers Media S.A. 2021-02-05 /pmc/articles/PMC7892961/ /pubmed/33613317 http://dx.doi.org/10.3389/fphys.2021.625950 Text en Copyright © 2021 Bergens, Nilsson, Papaioannou and Kadi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Bergens, Oscar Nilsson, Andreas Papaioannou, Konstantinos-Georgios Kadi, Fawzi Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults |
title | Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults |
title_full | Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults |
title_fullStr | Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults |
title_full_unstemmed | Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults |
title_short | Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults |
title_sort | sedentary patterns and systemic inflammation: sex-specific links in older adults |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892961/ https://www.ncbi.nlm.nih.gov/pubmed/33613317 http://dx.doi.org/10.3389/fphys.2021.625950 |
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