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Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults

The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring of sedentary patterns and PA was conducted i...

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Autores principales: Bergens, Oscar, Nilsson, Andreas, Papaioannou, Konstantinos-Georgios, Kadi, Fawzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892961/
https://www.ncbi.nlm.nih.gov/pubmed/33613317
http://dx.doi.org/10.3389/fphys.2021.625950
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author Bergens, Oscar
Nilsson, Andreas
Papaioannou, Konstantinos-Georgios
Kadi, Fawzi
author_facet Bergens, Oscar
Nilsson, Andreas
Papaioannou, Konstantinos-Georgios
Kadi, Fawzi
author_sort Bergens, Oscar
collection PubMed
description The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring of sedentary patterns and PA was conducted in a population of older men (n = 83; age: 67.4 ± 1.5; height: 178.7 ± 6.6 cm; weight: 80.9 ± 10.6 kg) and women (n = 146; age: 67.4 ± 1.6; height: 164.2 ± 6.1 cm; weight: 64.6 ± 10.1 kg) aged 65–70. Blood samples were collected for the assessment of the inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, IL-18, and monocyte chemoattractant protein-1 (MCP-1). Data were analyzed using multiple linear regression models. Total and bouts of ≥10 min of sedentary time were inversely associated with the anti-inflammatory marker IL-10 in older men (accumulated sedentary time: β = −0.116; bouts: β = −0.099; all p < 0.05). Associations were independent of moderate-to-vigorous physical activity (MVPA) and total PA volume. In women, total and bouts of ≥10 min of sedentary time were detrimentally associated with the pro-inflammatory marker fibrinogen (accumulated sedentary time: β = −0.130; bouts: β = −0.085; all p < 0.05). Associations remained between accumulated sedentary time and fibrinogen when adjusting for MVPA and total PA volume. This study highlights sex-specific routes by which sedentary patterns impact on pro- and anti-inflammatory biomarkers in older adults. The findings support efforts to promote accumulation of time spent in PA at the expense of time in sedentary pursuits on low-grade inflammation in older men and women.
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spelling pubmed-78929612021-02-20 Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults Bergens, Oscar Nilsson, Andreas Papaioannou, Konstantinos-Georgios Kadi, Fawzi Front Physiol Physiology The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring of sedentary patterns and PA was conducted in a population of older men (n = 83; age: 67.4 ± 1.5; height: 178.7 ± 6.6 cm; weight: 80.9 ± 10.6 kg) and women (n = 146; age: 67.4 ± 1.6; height: 164.2 ± 6.1 cm; weight: 64.6 ± 10.1 kg) aged 65–70. Blood samples were collected for the assessment of the inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, IL-18, and monocyte chemoattractant protein-1 (MCP-1). Data were analyzed using multiple linear regression models. Total and bouts of ≥10 min of sedentary time were inversely associated with the anti-inflammatory marker IL-10 in older men (accumulated sedentary time: β = −0.116; bouts: β = −0.099; all p < 0.05). Associations were independent of moderate-to-vigorous physical activity (MVPA) and total PA volume. In women, total and bouts of ≥10 min of sedentary time were detrimentally associated with the pro-inflammatory marker fibrinogen (accumulated sedentary time: β = −0.130; bouts: β = −0.085; all p < 0.05). Associations remained between accumulated sedentary time and fibrinogen when adjusting for MVPA and total PA volume. This study highlights sex-specific routes by which sedentary patterns impact on pro- and anti-inflammatory biomarkers in older adults. The findings support efforts to promote accumulation of time spent in PA at the expense of time in sedentary pursuits on low-grade inflammation in older men and women. Frontiers Media S.A. 2021-02-05 /pmc/articles/PMC7892961/ /pubmed/33613317 http://dx.doi.org/10.3389/fphys.2021.625950 Text en Copyright © 2021 Bergens, Nilsson, Papaioannou and Kadi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Bergens, Oscar
Nilsson, Andreas
Papaioannou, Konstantinos-Georgios
Kadi, Fawzi
Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults
title Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults
title_full Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults
title_fullStr Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults
title_full_unstemmed Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults
title_short Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults
title_sort sedentary patterns and systemic inflammation: sex-specific links in older adults
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892961/
https://www.ncbi.nlm.nih.gov/pubmed/33613317
http://dx.doi.org/10.3389/fphys.2021.625950
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