TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS

Binding of tumour necrosis factor α (TNFα) to its receptor (TNFR1) is critical for both survival and death cellular pathways. TNFα/TNFR1 signalling is complex and tightly regulated at different levels to control cell fate decisions. Previously, we identified TNFR1-d2, an exon 2-spliced transcript of...

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Detalles Bibliográficos
Autores principales: Rittore, Cécile, Méchin, Déborah, Sanchez, Elodie, Marinèche, Léa, Ea, Vuthy, Soler, Stephan, Vereecke, Marion, Mallavialle, Aude, Richard, Eric, Duroux-Richard, Isabelle, Apparailly, Florence, Touitou, Isabelle, Grandemange, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893027/
https://www.ncbi.nlm.nih.gov/pubmed/33603056
http://dx.doi.org/10.1038/s41598-021-83539-9

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