Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Regulatory CD4(+) T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we analyze Treg clonal origin in breast cancer pati...

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Detalles Bibliográficos
Autores principales: Xydia, Maria, Rahbari, Raheleh, Ruggiero, Eliana, Macaulay, Iain, Tarabichi, Maxime, Lohmayer, Robert, Wilkening, Stefan, Michels, Tillmann, Brown, Daniel, Vanuytven, Sebastiaan, Mastitskaya, Svetlana, Laidlaw, Sean, Grabe, Niels, Pritsch, Maria, Fronza, Raffaele, Hexel, Klaus, Schmitt, Steffen, Müller-Steinhardt, Michael, Halama, Niels, Domschke, Christoph, Schmidt, Manfred, von Kalle, Christof, Schütz, Florian, Voet, Thierry, Beckhove, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893042/
https://www.ncbi.nlm.nih.gov/pubmed/33602930
http://dx.doi.org/10.1038/s41467-021-21297-y

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