Histamine H(1) receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Negative symptoms in schizophrenia strongly contribute to poor functional outcomes, however its pathogenesis is still unclear. Here, we found that histamine H(1) receptor (H(1)R) expression in basal forebrain (BF) cholinergic neurons was decreased in patients with schizophrenia having negative sympt...

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Detalles Bibliográficos
Autores principales: Cheng, Li, Xu, Cenglin, Wang, Lu, An, Dadao, Jiang, Lei, Zheng, Yanrong, Xu, Yixin, Wang, Yi, Wang, Yujing, Zhang, Kuo, Wang, Xiaodong, Zhang, Xiangnan, Bao, Aimin, Zhou, Yudong, Yang, Jingyu, Duan, Shumin, Swaab, Dick F., Hu, Weiwei, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893046/
https://www.ncbi.nlm.nih.gov/pubmed/33602941
http://dx.doi.org/10.1038/s41467-021-21476-x

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