Sensitive protein misfolding cyclic amplification of sporadic Creutzfeldt–Jakob disease prions is strongly seed and substrate dependent

Unlike variant Creutzfeldt–Jakob disease prions, sporadic Creutzfeldt–Jakob disease prions have been shown to be difficult to amplify in vitro by protein misfolding cyclic amplification (PMCA). We assessed PMCA of pathological prion protein (PrP(TSE)) from 14 human sCJD brain samples in 3 substrates...

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Detalles Bibliográficos
Autores principales: Bélondrade, Maxime, Nicot, Simon, Mayran, Charly, Bruyere-Ostells, Lilian, Almela, Florian, Di Bari, Michele A., Levavasseur, Etienne, Watts, Joel C., Fournier-Wirth, Chantal, Lehmann, Sylvain, Haïk, Stéphane, Nonno, Romolo, Bougard, Daisy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893054/
https://www.ncbi.nlm.nih.gov/pubmed/33603091
http://dx.doi.org/10.1038/s41598-021-83630-1

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