Cargando…

IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate

Inhibitors of apoptosis proteins (IAPs) are conserved regulators involved in cell cycle, cell migration, cell death, immunity and inflammation, should be due to the fact that they can assist with the ability to cope with different kinds of extrinsic or intrinsic stresses. Bivalve molluscs are well a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Xiaomei, Zhang, Fengmei, Lian, Shanshan, Wang, Yinghui, Hu, Naina, Chen, Xiaomei, Dai, Xiaoting, Hu, Xiaoli, Wang, Shi, Bao, Zhenmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893105/
https://www.ncbi.nlm.nih.gov/pubmed/33613325
http://dx.doi.org/10.3389/fphys.2021.633301
_version_ 1783652996667670528
author Zhu, Xiaomei
Zhang, Fengmei
Lian, Shanshan
Wang, Yinghui
Hu, Naina
Chen, Xiaomei
Dai, Xiaoting
Hu, Xiaoli
Wang, Shi
Bao, Zhenmin
author_facet Zhu, Xiaomei
Zhang, Fengmei
Lian, Shanshan
Wang, Yinghui
Hu, Naina
Chen, Xiaomei
Dai, Xiaoting
Hu, Xiaoli
Wang, Shi
Bao, Zhenmin
author_sort Zhu, Xiaomei
collection PubMed
description Inhibitors of apoptosis proteins (IAPs) are conserved regulators involved in cell cycle, cell migration, cell death, immunity and inflammation, should be due to the fact that they can assist with the ability to cope with different kinds of extrinsic or intrinsic stresses. Bivalve molluscs are well adapted to highly complex marine environments. As free-living filter feeders that may take toxic dinoflagellates as food, bivalves can accumulate and put up with significant levels of paralytic shellfish toxins (PSTs). PSTs absorption and accumulation could have a deleterious effect on bivalves, causing negative impact on their feeding and digestion capabilities. In the present study, we analyzed IAP genes (PyIAPs) in Yesso scallop (Patinopecten yessoensis), a major fishery and aquaculture species in China. Forty-seven PyIAPs from five sub-families were identified, and almost half of the PyIAP genes were localized in clusters on two chromosomes. Several sites under positive selection was revealed in the significantly expanded sub-families BIRC4 and BIRC5. After exposure to PST-producing dinoflagellates, Alexandrium catenella, fourteen PyIAPs showed significant responses in hepatopancreas and kidney, and more than eighty-five percent of them were from the expanded sub-families BIRC4 and BIRC5. The regulation pattern of PyIAPs was similar between the two tissues, with more than half exhibited expression suppression within three days after exposure. In contrast to hepatopancreas, more acute changes of PyIAPs expression could be detected in kidney, suggesting the possible involvement of these PyIAPs in tissue-specific PST tolerance. These findings also imply the adaptive expansion of bivalve IAP genes in response to algae derived biotoxins.
format Online
Article
Text
id pubmed-7893105
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78931052021-02-20 IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate Zhu, Xiaomei Zhang, Fengmei Lian, Shanshan Wang, Yinghui Hu, Naina Chen, Xiaomei Dai, Xiaoting Hu, Xiaoli Wang, Shi Bao, Zhenmin Front Physiol Physiology Inhibitors of apoptosis proteins (IAPs) are conserved regulators involved in cell cycle, cell migration, cell death, immunity and inflammation, should be due to the fact that they can assist with the ability to cope with different kinds of extrinsic or intrinsic stresses. Bivalve molluscs are well adapted to highly complex marine environments. As free-living filter feeders that may take toxic dinoflagellates as food, bivalves can accumulate and put up with significant levels of paralytic shellfish toxins (PSTs). PSTs absorption and accumulation could have a deleterious effect on bivalves, causing negative impact on their feeding and digestion capabilities. In the present study, we analyzed IAP genes (PyIAPs) in Yesso scallop (Patinopecten yessoensis), a major fishery and aquaculture species in China. Forty-seven PyIAPs from five sub-families were identified, and almost half of the PyIAP genes were localized in clusters on two chromosomes. Several sites under positive selection was revealed in the significantly expanded sub-families BIRC4 and BIRC5. After exposure to PST-producing dinoflagellates, Alexandrium catenella, fourteen PyIAPs showed significant responses in hepatopancreas and kidney, and more than eighty-five percent of them were from the expanded sub-families BIRC4 and BIRC5. The regulation pattern of PyIAPs was similar between the two tissues, with more than half exhibited expression suppression within three days after exposure. In contrast to hepatopancreas, more acute changes of PyIAPs expression could be detected in kidney, suggesting the possible involvement of these PyIAPs in tissue-specific PST tolerance. These findings also imply the adaptive expansion of bivalve IAP genes in response to algae derived biotoxins. Frontiers Media S.A. 2021-02-05 /pmc/articles/PMC7893105/ /pubmed/33613325 http://dx.doi.org/10.3389/fphys.2021.633301 Text en Copyright © 2021 Zhu, Zhang, Lian, Wang, Hu, Chen, Dai, Hu, Wang and Bao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhu, Xiaomei
Zhang, Fengmei
Lian, Shanshan
Wang, Yinghui
Hu, Naina
Chen, Xiaomei
Dai, Xiaoting
Hu, Xiaoli
Wang, Shi
Bao, Zhenmin
IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate
title IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate
title_full IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate
title_fullStr IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate
title_full_unstemmed IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate
title_short IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate
title_sort iaps gene expansion in the scallop patinopecten yessoensis and their expression profiles after exposure to the toxic dinoflagellate
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893105/
https://www.ncbi.nlm.nih.gov/pubmed/33613325
http://dx.doi.org/10.3389/fphys.2021.633301
work_keys_str_mv AT zhuxiaomei iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT zhangfengmei iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT lianshanshan iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT wangyinghui iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT hunaina iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT chenxiaomei iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT daixiaoting iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT huxiaoli iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT wangshi iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate
AT baozhenmin iapsgeneexpansioninthescalloppatinopectenyessoensisandtheirexpressionprofilesafterexposuretothetoxicdinoflagellate