Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional factors GLI through bromodomain-containing protein 4 (...

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Detalles Bibliográficos
Autores principales: Liu, Xiaohua, Zhang, Yu, Li, Yalei, Wang, Juan, Ding, Huaqian, Huang, Wenjing, Ding, Chunyong, Liu, Hongchun, Tan, Wenfu, Zhang, Ao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893122/
https://www.ncbi.nlm.nih.gov/pubmed/33643826
http://dx.doi.org/10.1016/j.apsb.2020.07.007

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