Cargando…

DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/β-catenin pathway

Long noncoding RNA DiGeorge syndrome critical region gene 5 (DGCR5) has been shown to be highly associated with cancer development. However, the biological role and molecular mechanism of DGCR5 in pancreatic cancer (PC) remains largely unknown. This study aimed to explore the role of DGCR5 in PC. It...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shi-lei, Cai, Chen, Yang, Zi-yi, Wu, Zi-you, Wu, Xiang-song, Wang, Xue-feng, Dong, Ping, Gong, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893588/ https://www.ncbi.nlm.nih.gov/pubmed/33613108 http://dx.doi.org/10.7150/ijbs.55636

Ejemplares similares

Reciprocal regulation of DGCR5 and miR-320a affects the cellular malignant phenotype and 5-FU response in pancreatic ductal adenocarcinoma
por: Yong, Sun, et al.
Publicado: (2017)

MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway
por: Zhou, Wei, et al.
Publicado: (2015)

DGCR5 Promotes Gallbladder Cancer by Sponging MiR-3619-5p via MEK/ERK1/2 and JNK/p38 MAPK Pathways
por: Liu, Shilei, et al.
Publicado: (2020)

Hypoxia Activates SOX5/Wnt/β-Catenin Signaling by Suppressing MiR-338-3p in Gastric Cancer
por: Zheng, Jing-jing, et al.
Publicado: (2020)

The expression of miR-513c and miR-3163 was downregulated in tumor tissues compared with normal adjacent tissue of patients with breast cancer
por: Delgir, Soheila, et al.
Publicado: (2021)

The effects of aberrant expression of LncRNA DGCR5/miR‐873‐5p/TUSC3 in lung cancer cell progression
por: Luo, Judong, et al.
Publicado: (2018)

miR-106b-5p promotes renal cell carcinoma aggressiveness and stem-cell-like phenotype by activating Wnt/β-catenin signalling
por: Lu, Jun, et al.
Publicado: (2017)

LncRNA DGCR5 plays a tumor-suppressive role in glioma via the miR-21/Smad7 and miR-23a/PTEN axes
por: He, Zongze, et al.
Publicado: (2020)

LncRNA BANCR Promotes Pancreatic Cancer Tumorigenesis via Modulating MiR-195-5p/Wnt/β-Catenin Signaling Pathway
por: Wu, Xinquan, et al.
Publicado: (2019)

Large-Scale Analysis Reveals the Specific Clinical and Immune Features of DGCR5 in Glioma
por: Wu, Xuechao, et al.
Publicado: (2020)

Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling
por: Li, Yun, et al.
Publicado: (2019)

LHC MDs 3163, 3164, and 3166: Injection oscillations throughout the cycle
por: Timko, Helga, et al.
Publicado: (2019)

3163 A Systematic Review of Research Competency Assessments for Clinical Researchers
por: Ianni, Phillip A, et al.
Publicado: (2019)

lncRNA DGCR 5/miR-27a-3p/BNIP3 promotes cell apoptosis in pancreatic cancer by regulating the p38 MAPK pathway
por: Li, Xianjie, et al.
Publicado: (2020)

miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation
por: Zhu, Ningxia, et al.
Publicado: (2018)

Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations
por: Hart, Matthew R., et al.
Publicado: (2018)

FGD5-AS1 is an oncogenic lncRNA in pancreatic cancer and regulates the Wnt/β-catenin signaling pathway via miR-577
por: Zhang, Wei-Tao, et al.
Publicado: (2022)

Increased m(6)A modification of lncRNA DBH-AS1 suppresses pancreatic cancer growth and gemcitabine resistance via the miR-3163/USP44 axis
por: Ye, Xin, et al.
Publicado: (2022)

LncRNA FOXP4-AS1 is activated by PAX5 and promotes the growth of prostate cancer by sequestering miR-3184-5p to upregulate FOXP4
por: Wu, Xingcheng, et al.
Publicado: (2019)

MiR-122-5p promotes peritoneal fibrosis in a rat model of peritoneal dialysis by targeting Smad5 to activate Wnt/β-catenin pathway
por: Liu, Yirong, et al.
Publicado: (2022)

Inhibition of Circulating miR-194-5p Reverses Osteoporosis through Wnt5a/β-Catenin-Dependent Induction of Osteogenic Differentiation
por: Mi, Bobin, et al.
Publicado: (2020)

miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/β-Catenin Signaling
por: Zhang, Ying-Hui, et al.
Publicado: (2021)

miR-576-5p promotes epithelial-to-mesenchymal transition in colorectal cancer by targeting the Wnt5a-mediated Wnt/β-catenin signaling pathway
por: Luo, Jialin, et al.
Publicado: (2021)

Long non-coding FAM201A accelerates the tumorigenesis and progression of colorectal cancer through miR-3163/MACC1 axis
por: Zeng, Lifeng, et al.
Publicado: (2022)

Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity
por: Westfall, Trudi A., et al.
Publicado: (2003)

miR-501-3p promotes colorectal cancer progression via activation of Wnt/β-catenin signaling
por: Wu, Fangxiong, et al.
Publicado: (2019)

Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer
por: Fan, Dongmei, et al.
Publicado: (2016)

Activating transcription factor 5 (ATF5) promotes tumorigenic capability and activates the Wnt/b-catenin pathway in bladder cancer
por: Zhou, Junhao, et al.
Publicado: (2021)

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes
por: Zhou, Cefan, et al.
Publicado: (2020)

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling
por: Pan, Jinchang, et al.
Publicado: (2020)

Pax5 mediates the transcriptional activation of the CD81 gene
por: Hosokawa, Kohei, et al.
Publicado: (2021)

MEX3A promotes nasopharyngeal carcinoma progression via the miR-3163/SCIN axis by regulating NF-κB signaling pathway
por: Xiang, Xin-xin, et al.
Publicado: (2022)

DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway
por: Wang, Qingqing, et al.
Publicado: (2023)

miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway
por: Zhang, Zhuhong, et al.
Publicado: (2016)

DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2
por: Nogami, Masahiro, et al.
Publicado: (2021)

MiR-26a-5p as a useful therapeutic target for upper tract urothelial carcinoma by regulating WNT5A/β-catenin signaling
por: Chung, Yueh-Hua, et al.
Publicado: (2022)

LncRNA DGCR5 Isoform-1 Silencing Suppresses the Malignant Phenotype of Clear Cell Renal Cell Carcinoma via miR-211-5p/Snail Signal Axis
por: Zhong, Guang-Xin, et al.
Publicado: (2021)

Hsa-mir-3163 and CCNB1 may be potential biomarkers and therapeutic targets for androgen receptor positive triple-negative breast cancer
por: Qiu, Pengjun, et al.
Publicado: (2021)

miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway
por: Tan, Lulu, et al.
Publicado: (2022)

Aflatoxin B(1) Negatively Regulates Wnt/β-Catenin Signaling Pathway through Activating miR-33a
por: Fang, Yi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_sbkugtgi3o96epeukkmd6hiil5