COVID-19—from mucosal immunology to IBD patients

Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current under...

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Detalles Bibliográficos
Autores principales: Weidinger, Carl, Hegazy, Ahmed Nabil, Glauben, Rainer, Siegmund, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The authors. Published by Elsevier Inc. 2021
Materias:
Review-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893623/
https://www.ncbi.nlm.nih.gov/pubmed/33608656
http://dx.doi.org/10.1038/s41385-021-00384-9
Descripción
Sumario:Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.

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