COVID-19—from mucosal immunology to IBD patients

Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current under...

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Autores principales: Weidinger, Carl, Hegazy, Ahmed Nabil, Glauben, Rainer, Siegmund, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The authors. Published by Elsevier Inc. 2021
Materias:
Review-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893623/
https://www.ncbi.nlm.nih.gov/pubmed/33608656
http://dx.doi.org/10.1038/s41385-021-00384-9
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author Weidinger, Carl
Hegazy, Ahmed Nabil
Glauben, Rainer
Siegmund, Britta
author_facet Weidinger, Carl
Hegazy, Ahmed Nabil
Glauben, Rainer
Siegmund, Britta
author_sort Weidinger, Carl
collection PubMed
description Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.
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spelling pubmed-78936232021-02-19 COVID-19—from mucosal immunology to IBD patients Weidinger, Carl Hegazy, Ahmed Nabil Glauben, Rainer Siegmund, Britta Mucosal Immunol Review-Article Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals. The authors. Published by Elsevier Inc. 2021-05 2022-12-31 /pmc/articles/PMC7893623/ /pubmed/33608656 http://dx.doi.org/10.1038/s41385-021-00384-9 Text en Copyright © 2021 The authors. Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review-Article
Weidinger, Carl
Hegazy, Ahmed Nabil
Glauben, Rainer
Siegmund, Britta
COVID-19—from mucosal immunology to IBD patients
title COVID-19—from mucosal immunology to IBD patients
title_full COVID-19—from mucosal immunology to IBD patients
title_fullStr COVID-19—from mucosal immunology to IBD patients
title_full_unstemmed COVID-19—from mucosal immunology to IBD patients
title_short COVID-19—from mucosal immunology to IBD patients
title_sort covid-19—from mucosal immunology to ibd patients
topic Review-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893623/
https://www.ncbi.nlm.nih.gov/pubmed/33608656
http://dx.doi.org/10.1038/s41385-021-00384-9
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