Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities

[Image: see text] Brain cancer effected around estimated 23 890 adults and 3540 children under the age of 15 in 2020. The chemotherapeutic agents that are already approved by the FDA for brain cancer are proving to be not highly effective because of the interference from the tumor microenvironment a...

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Autores principales: McCord, Eva, Pawar, Shreya, Koneru, Tejaswi, Tatiparti, Katyayani, Sau, Samaresh, Iyer, Arun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893640/
https://www.ncbi.nlm.nih.gov/pubmed/33623837
http://dx.doi.org/10.1021/acsomega.0c05500
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author McCord, Eva
Pawar, Shreya
Koneru, Tejaswi
Tatiparti, Katyayani
Sau, Samaresh
Iyer, Arun K.
author_facet McCord, Eva
Pawar, Shreya
Koneru, Tejaswi
Tatiparti, Katyayani
Sau, Samaresh
Iyer, Arun K.
author_sort McCord, Eva
collection PubMed
description [Image: see text] Brain cancer effected around estimated 23 890 adults and 3540 children under the age of 15 in 2020. The chemotherapeutic agents that are already approved by the FDA for brain cancer are proving to be not highly effective because of the interference from the tumor microenvironment as well as their own toxicities. Added to this is the impedance presented by the extremely restrictive permeability of the blood brain barrier (BBB). Targeted nanoparticulate drug delivery systems offer a good opportunity to traverse the BBB and selectively target the tumor cells. Folate receptors are found to be one of the most useful targets for drug delivery to the brain. Hence, this Mini-Review discusses the folate receptors and their application in the treatment of brain cancers using targeted nanoparticles.
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spelling pubmed-78936402021-02-22 Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities McCord, Eva Pawar, Shreya Koneru, Tejaswi Tatiparti, Katyayani Sau, Samaresh Iyer, Arun K. ACS Omega [Image: see text] Brain cancer effected around estimated 23 890 adults and 3540 children under the age of 15 in 2020. The chemotherapeutic agents that are already approved by the FDA for brain cancer are proving to be not highly effective because of the interference from the tumor microenvironment as well as their own toxicities. Added to this is the impedance presented by the extremely restrictive permeability of the blood brain barrier (BBB). Targeted nanoparticulate drug delivery systems offer a good opportunity to traverse the BBB and selectively target the tumor cells. Folate receptors are found to be one of the most useful targets for drug delivery to the brain. Hence, this Mini-Review discusses the folate receptors and their application in the treatment of brain cancers using targeted nanoparticles. American Chemical Society 2021-02-01 /pmc/articles/PMC7893640/ /pubmed/33623837 http://dx.doi.org/10.1021/acsomega.0c05500 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle McCord, Eva
Pawar, Shreya
Koneru, Tejaswi
Tatiparti, Katyayani
Sau, Samaresh
Iyer, Arun K.
Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities
title Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities
title_full Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities
title_fullStr Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities
title_full_unstemmed Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities
title_short Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities
title_sort folate receptors’ expression in gliomas may possess potential nanoparticle-based drug delivery opportunities
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893640/
https://www.ncbi.nlm.nih.gov/pubmed/33623837
http://dx.doi.org/10.1021/acsomega.0c05500
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