Cargando…

The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?

Lower back pain (LBP) is one of the most common reasons for seeking medical advice in orthopedic clinics. Increasingly, research has shown that symptomatic intervertebral disc degeneration (IDD) is mostly related to LBP. This review first outlines the research and findings of studies into IDD, from...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yongjin, Liu, Shen, Pan, Dayu, Xu, Baoshan, Xing, Xuewu, Zhou, Hengxing, Zhang, Bin, Zhou, Suzhe, Ning, Guangzhi, Feng, Shiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893690/
https://www.ncbi.nlm.nih.gov/pubmed/33537810
http://dx.doi.org/10.3892/mmr.2021.11878
_version_ 1783653096769978368
author Li, Yongjin
Liu, Shen
Pan, Dayu
Xu, Baoshan
Xing, Xuewu
Zhou, Hengxing
Zhang, Bin
Zhou, Suzhe
Ning, Guangzhi
Feng, Shiqing
author_facet Li, Yongjin
Liu, Shen
Pan, Dayu
Xu, Baoshan
Xing, Xuewu
Zhou, Hengxing
Zhang, Bin
Zhou, Suzhe
Ning, Guangzhi
Feng, Shiqing
author_sort Li, Yongjin
collection PubMed
description Lower back pain (LBP) is one of the most common reasons for seeking medical advice in orthopedic clinics. Increasingly, research has shown that symptomatic intervertebral disc degeneration (IDD) is mostly related to LBP. This review first outlines the research and findings of studies into IDD, from the physiological structure of the intervertebral disc (IVD) to various pathological cascades. The vicious cycles of IDD are re-described in relation to the analysis of the relationship among the pathological mechanisms involved in IDD. Interestingly, a ‘chief molecule’ was found, hypoxia-inducible factor-1α (HIF-1α), that may regulate all other mechanisms involved in IDD. When the vicious cycle is established, the low oxygen tension activates the expression of HIF-1α, which subsequently enters into the hypoxia-induced HIF pathways. The HIF pathways are dichotomized as friend and foe pathways according to the oxygen tension of the IVD microenvironment. Combined with clinical outcomes and previous research, the trend of IDD development has been predicted in this paper. Lastly, an early precautionary diagnosis and treatment method is proposed whereby nucleus pulposus tissue for biopsy can be obtained through IVD puncture guided by B-ultrasound when the patient is showing symptoms but MRI imaging shows negative results. The assessment criteria for biopsy and the feasibility, superiority and challenges of this approach have been discussed. Overall, it is clear that HIF-1α is an indispensable reference indicator for the accurate diagnosis and treatment of IDD.
format Online
Article
Text
id pubmed-7893690
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-78936902021-03-08 The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe? Li, Yongjin Liu, Shen Pan, Dayu Xu, Baoshan Xing, Xuewu Zhou, Hengxing Zhang, Bin Zhou, Suzhe Ning, Guangzhi Feng, Shiqing Mol Med Rep Review Lower back pain (LBP) is one of the most common reasons for seeking medical advice in orthopedic clinics. Increasingly, research has shown that symptomatic intervertebral disc degeneration (IDD) is mostly related to LBP. This review first outlines the research and findings of studies into IDD, from the physiological structure of the intervertebral disc (IVD) to various pathological cascades. The vicious cycles of IDD are re-described in relation to the analysis of the relationship among the pathological mechanisms involved in IDD. Interestingly, a ‘chief molecule’ was found, hypoxia-inducible factor-1α (HIF-1α), that may regulate all other mechanisms involved in IDD. When the vicious cycle is established, the low oxygen tension activates the expression of HIF-1α, which subsequently enters into the hypoxia-induced HIF pathways. The HIF pathways are dichotomized as friend and foe pathways according to the oxygen tension of the IVD microenvironment. Combined with clinical outcomes and previous research, the trend of IDD development has been predicted in this paper. Lastly, an early precautionary diagnosis and treatment method is proposed whereby nucleus pulposus tissue for biopsy can be obtained through IVD puncture guided by B-ultrasound when the patient is showing symptoms but MRI imaging shows negative results. The assessment criteria for biopsy and the feasibility, superiority and challenges of this approach have been discussed. Overall, it is clear that HIF-1α is an indispensable reference indicator for the accurate diagnosis and treatment of IDD. D.A. Spandidos 2021-04 2021-01-28 /pmc/articles/PMC7893690/ /pubmed/33537810 http://dx.doi.org/10.3892/mmr.2021.11878 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Li, Yongjin
Liu, Shen
Pan, Dayu
Xu, Baoshan
Xing, Xuewu
Zhou, Hengxing
Zhang, Bin
Zhou, Suzhe
Ning, Guangzhi
Feng, Shiqing
The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
title The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
title_full The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
title_fullStr The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
title_full_unstemmed The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
title_short The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
title_sort potential role and trend of hif-1α in intervertebral disc degeneration: friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893690/
https://www.ncbi.nlm.nih.gov/pubmed/33537810
http://dx.doi.org/10.3892/mmr.2021.11878
work_keys_str_mv AT liyongjin thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT liushen thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT pandayu thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT xubaoshan thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT xingxuewu thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT zhouhengxing thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT zhangbin thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT zhousuzhe thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT ningguangzhi thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT fengshiqing thepotentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT liyongjin potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT liushen potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT pandayu potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT xubaoshan potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT xingxuewu potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT zhouhengxing potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT zhangbin potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT zhousuzhe potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT ningguangzhi potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe
AT fengshiqing potentialroleandtrendofhif1ainintervertebraldiscdegenerationfriendorfoe