Cargando…

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis

BACKGROUND: The integrin VLA-4 (α4β1) plays an important role in leukocyte trafficking. This study investigated the efficacy of a novel topical α4β1 integrin inhibitor (GW559090, GW) in a mouse model for non-infectious posterior uveitis (experimental autoimmune uveitis; EAU) and its effect on intrao...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yi Hsing, Eskandarpour, Malihe, Zhang, Xiaozhe, Galatowicz, Grazyna, Greenwood, John, Lightman, Sue, Calder, Virginia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893745/ https://www.ncbi.nlm.nih.gov/pubmed/33602234 http://dx.doi.org/10.1186/s12974-021-02080-8

Ejemplares similares

Adhesion Molecule Targeted Therapy for Non-Infectious Uveitis
por: Chen, Yi-Hsing, et al.
Publicado: (2022)

Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT
por: Gilbert, Rose M., et al.
Publicado: (2018)

Immune-Mediated Retinal Vasculitis in Posterior Uveitis and Experimental Models: The Leukotriene (LT)B4-VEGF Axis
por: Eskandarpour, Malihe, et al.
Publicado: (2021)

Statin Modulation of Human T-Cell Proliferation, IL-1β and IL-17 Production, and IFN-γ T Cell Expression: Synergy with Conventional Immunosuppressive Agents
por: Jameel, Ashmal, et al.
Publicado: (2013)

CD4(+) T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease
por: Chen, Yi-Hsing, et al.
Publicado: (2021)

Allergic eye disease: Blocking LTB4/C5 in vivo suppressed disease and Th2 & Th9 cells
por: Eskandarpour, Malihe, et al.
Publicado: (2021)

Is IL-10 a Good Target to Inhibit Choroidal Neovascularisation in Age-Related Macular Disease?
por: Lightman, Sue, et al.
Publicado: (2006)

PPAR-γ Agonist GW1929 But Not Antagonist GW9662 Reduces TBBPA-Induced Neurotoxicity in Primary Neocortical Cells
por: Wojtowicz, Anna K., et al.
Publicado: (2013)

GW Stewart
por: Kilmer, Misha E, et al.
Publicado: (2010)

Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in culture
Publicado: (1992)

Mammalian GW220/TNGW1 is essential for the formation of GW/P bodies containing miRISC
por: Castilla-Llorente, Virginia, et al.
Publicado: (2012)

Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins
Publicado: (1995)

Cell adhesion and migration are regulated at distinct stages of thymic T cell development: the roles of fibronectin, VLA4, and VLA5
Publicado: (1996)

ROSAT/ASCA/VLA studies of solar proxies
por: Güdel, M, et al.
Publicado: (1996)

Programming in GW-BASIC
por: McBride, P K
Publicado: (1991)

Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species
por: Soto-Diaz, Katiria, et al.
Publicado: (2021)

Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease
por: Mills, Clare, et al.
Publicado: (2022)

A Review of Antimicrobial Therapy for Infectious Uveitis of the Posterior Segment
por: Sallam, Ahmed B, et al.
Publicado: (2018)

Can Simvastatin Reduce the Need for Immunomodulatory Drugs to Treat Uveitis?: A Prospective, Randomized, Placebo-Controlled Trial
por: Al-Janabi, Ahmed, et al.
Publicado: (2023)

Coalescence of Kerr Black Holes—Binary Systems from GW150914 to GW170814
por: Gwak, Bogeun
Publicado: (2019)

Polypoidal Choroidal Vasculopathy Complicating Retinal Laser in Quiescent Uveitis
por: Burke, Tomas R., et al.
Publicado: (2019)

Workshop on GW Data Analysis
Publicado: (1997)

Instant MinGW starter
por: Shpigor, Ilya
Publicado: (2013)

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis
Publicado: (1991)

CNS accumulation of regulatory B cells is VLA-4-dependent
por: Lehmann-Horn, Klaus, et al.
Publicado: (2016)

Integrin-directed antibody-based immunotherapy: focus on VLA-4
por: Savino, Wilson, et al.
Publicado: (2021)

The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression
por: Chekulaeva, Marina, et al.
Publicado: (2010)

In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia
por: Ruan, Yongsheng, et al.
Publicado: (2022)

GW-BASIC a su alcance
por: Albrecht, Bob, 1930-
Publicado: (1990)

What is the source of the PTA GW signal?
por: Ellis, John, et al.
Publicado: (2023)

The GW/BSE Method in Magnetic Fields
por: Holzer, Christof, et al.
Publicado: (2021)

Pharmacodynamic Consequences of Administration of VLA-4 Antagonist CDP323 to Multiple Sclerosis Subjects: A Randomized, Double-Blind Phase 1/2 Study
por: Wolf, Christian, et al.
Publicado: (2013)

Regulation of the VLA integrin-ligand interactions through the beta 1 subunit
Publicado: (1992)

The L1 adhesion molecule is a cellular ligand for VLA-5
Publicado: (1995)

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
Publicado: (1995)

Expression and pathogenesis of VCAM-1 and VLA-4 cytokines in multiple myeloma
por: Hao, Pan, et al.
Publicado: (2020)

CC16 drives VLA-2-dependent SPLUNC1 expression
por: Iannuzo, Natalie, et al.
Publicado: (2023)

Adhesion Molecule Profile and the Effect of Anti-VLA-4 mAb Treatment in Experimental Autoimmune Encephalomyelitis, a Mouse Model of Multiple Sclerosis
por: Pyka-Fościak, Grażyna, et al.
Publicado: (2022)

Two-Component GW Calculations: Cubic Scaling Implementation and Comparison of Vertex-Corrected and Partially Self-Consistent GW Variants
por: Förster, Arno, et al.
Publicado: (2023)

Comments on Graviton Propagation in Light of GW150914
por: Ellis, John, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_phbc4jdq95v3ke3o13aknq8239