Cargando…

A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8

DOCK8 is a Cdc42-specific guanine-nucleotide exchange factor that is essential for development and functions of various subsets of leukocytes in innate and acquired immune responses. Although DOCK8 plays a critical role in spatial control of Cdc42 activity during interstitial leukocyte migration, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakurai, Tetsuya, Kukimoto-Niino, Mutsuko, Kunimura, Kazufumi, Yamane, Nana, Sakata, Daiji, Aihara, Ryosuke, Yasuda, Tomoharu, Yokoyama, Shigeyuki, Shirouzu, Mikako, Fukui, Yoshinori, Uruno, Takehito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893821/ https://www.ncbi.nlm.nih.gov/pubmed/33574036 http://dx.doi.org/10.26508/lsa.202000873

Ejemplares similares

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration
por: Terasawa, Masao, et al.
Publicado: (2012)

DOCK family proteins: key players in immune surveillance mechanisms
por: Kunimura, Kazufumi, et al.
Publicado: (2019)

The Rac Activator DOCK2 Mediates Plasma Cell Differentiation and IgG Antibody Production
por: Ushijima, Miho, et al.
Publicado: (2018)

Structural Insight into TNIK Inhibition
por: Kukimoto-Niino, Mutsuko, et al.
Publicado: (2022)

Identification of a functional DOCK8 gene polymorphism associated with atopic dermatitis
por: Kunimura, Kazufumi, et al.
Publicado: (2022)

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody–antigen interaction
por: Matsuda, Takayoshi, et al.
Publicado: (2018)

Cell-permeable Carboxyl-terminal p27(Kip1) Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase
por: Morishita, Daisuke, et al.
Publicado: (2011)

Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury
por: Morino, Kenji, et al.
Publicado: (2023)

Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib
por: Ohbayashi, Naomi, et al.
Publicado: (2018)

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex
por: Kukimoto-Niino, Mutsuko, et al.
Publicado: (2021)

Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells
por: Tatsuguchi, Takaaki, et al.
Publicado: (2022)

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
por: Shimizu, Kanako, et al.
Publicado: (2019)

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells
por: Terasawa, Kazue, et al.
Publicado: (2021)

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development
por: Kunimura, Kazufumi, et al.
Publicado: (2021)

Reduced efficacy of a Src kinase inhibitor in crowded protein solution
por: Kasahara, Kento, et al.
Publicado: (2021)

TNIK inhibition abrogates colorectal cancer stemness
por: Masuda, Mari, et al.
Publicado: (2016)

Targeting Ras-binding domain of ELMO1 by computational nanobody design
por: Tam, Chunlai, et al.
Publicado: (2023)

Content of intrinsic disorder influences the outcome of cell-free protein synthesis
por: Tokmakov, Alexander A., et al.
Publicado: (2015)

Topological Analysis of MAPK Cascade for Kinetic ErbB Signaling
por: Nakakuki, Takashi, et al.
Publicado: (2008)

Dictyostelium IQGAP-related Protein Specifically Involved in the Completion of Cytokinesis
por: Adachi, Hiroyuki, et al.
Publicado: (1997)

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
por: Yamamura, Kazuhiko, et al.
Publicado: (2017)

Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
por: Wakamori, Masatoshi, et al.
Publicado: (2015)

Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA
por: Nagano, Soshichiro, et al.
Publicado: (2015)

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation
por: Ogawa, Kana, et al.
Publicado: (2014)

Altered macrophage phenotypes in a case of autoimmune pulmonary alveolar proteinosis
por: Hata, Kentaro, et al.
Publicado: (2023)

Cell-Free Protein Synthesis Using S30 Extracts from Escherichia coli RFzero Strains for Efficient Incorporation of Non-Natural Amino Acids into Proteins
por: Adachi, Jiro, et al.
Publicado: (2019)

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
por: Mizuta, Hayato, et al.
Publicado: (2021)

Structural basis for promoter specificity switching of RNA polymerase by a phage factor
por: Tagami, Shunsuke, et al.
Publicado: (2014)

Expression, purification, crystallization and preliminary X-ray diffraction analysis of galactokinase from Pyrococcus horikoshii. Erratum
por: Inagaki, Eiji, et al.
Publicado: (2006)

Existence of two O-like intermediates in the photocycle of Acetabularia rhodopsin II, a light-driven proton pump from a marine alga
por: Tamogami, Jun, et al.
Publicado: (2017)

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation
por: Gotoh, Kazuhito, et al.
Publicado: (2010)

Expansion of ST2-expressing macrophages in a patient with bronchiolitis obliterans syndrome
por: Yanagihara, Toyoshi, et al.
Publicado: (2023)

The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation
por: Shoji, Shisako, et al.
Publicado: (2014)

The landscape of translational stall sites in bacteria revealed by monosome and disome profiling
por: Fujita, Tomoya, et al.
Publicado: (2022)

Biochemical and Biophysical Properties of Interactions between Subunits of the Peripheral Stalk Region of Human V-ATPase
por: Rahman, Suhaila, et al.
Publicado: (2013)

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin
por: Shinoda, Takehiro, et al.
Publicado: (2016)

Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseases
por: Hata, Kentaro, et al.
Publicado: (2023)

Crystal structure of tRNA m(1)A58 methyltransferase TrmI from Aquifex aeolicus in complex with S-adenosyl-l-methionine
por: Kuratani, Mitsuo, et al.
Publicado: (2014)

Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
por: Tochio, Naoya, et al.
Publicado: (2015)

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus
por: Yanagihara, Toyoshi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6juo2rt9g58k4c4n4s92cirkff