Cargando…

Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals

CONTEXT: Body composition may explain partially why non-obese individuals still at the risk of developing non-alcoholic fatty liver disease (NAFLD). The ratio of fat mass to fat-free mass (FM/FFM) has been proposed to assess the combined effect of different body compositions. OBJECTIVE: We aimed to...

Descripción completa

Detalles Bibliográficos
Autores principales: Dai, Huajie, Xiang, Jiali, Hou, Yanan, Xuan, Liping, Wang, Tiange, Li, Mian, Zhao, Zhiyun, Xu, Yu, Lu, Jieli, Chen, Yuhong, Wang, Weiqing, Ning, Guang, Bi, Yufang, Xu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893940/
https://www.ncbi.nlm.nih.gov/pubmed/33608033
http://dx.doi.org/10.1186/s12986-021-00551-6
_version_ 1783653148673441792
author Dai, Huajie
Xiang, Jiali
Hou, Yanan
Xuan, Liping
Wang, Tiange
Li, Mian
Zhao, Zhiyun
Xu, Yu
Lu, Jieli
Chen, Yuhong
Wang, Weiqing
Ning, Guang
Bi, Yufang
Xu, Min
author_facet Dai, Huajie
Xiang, Jiali
Hou, Yanan
Xuan, Liping
Wang, Tiange
Li, Mian
Zhao, Zhiyun
Xu, Yu
Lu, Jieli
Chen, Yuhong
Wang, Weiqing
Ning, Guang
Bi, Yufang
Xu, Min
author_sort Dai, Huajie
collection PubMed
description CONTEXT: Body composition may explain partially why non-obese individuals still at the risk of developing non-alcoholic fatty liver disease (NAFLD). The ratio of fat mass to fat-free mass (FM/FFM) has been proposed to assess the combined effect of different body compositions. OBJECTIVE: We aimed to investigate the associations of FM/FFM ratio with the risk of developing NAFLD and fibrosis and to identify the potential mediators according to obesity status. METHODS: This cohort study comprised 3419 adults age ≥ 40 years and free of NAFLD at baseline. Body composition was measured by bioelectrical impedance analysis. NAFLD was ascertained by ultrasonography and fibrosis was assessed by non-invasive score systems. RESULTS: For each 1 standard deviation increment in FM/FFM ratio, the odds ratio for the risk of NAFLD was 1.55 (95% confidence interval [CI] 1.23–1.95) in non-obese men, 1.33 (95% CI 1.08–1.65) in obese men, 1.42 (95% CI 1.44–1.67) in non-obese women, and 1.29 (95% CI 1.12–1.50) in obese women. Similar associations were also found between FM/FFM ratio and NAFLD with fibrosis. Mediation analysis showed that insulin resistance, triglycerides, high-density lipoprotein cholesterol, white blood cells, and total cholesterol mediated the association of FM/FFM ratio with NAFLD risk in specific sex and obesity subgroups. CONCLUSIONS: The FM/FFM ratio significantly associated with the NAFLD and fibrosis risk in both non-obese and obese individuals. Different factors may mediate the association between body composition and NAFLD risk according to different obesity status.
format Online
Article
Text
id pubmed-7893940
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-78939402021-02-22 Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals Dai, Huajie Xiang, Jiali Hou, Yanan Xuan, Liping Wang, Tiange Li, Mian Zhao, Zhiyun Xu, Yu Lu, Jieli Chen, Yuhong Wang, Weiqing Ning, Guang Bi, Yufang Xu, Min Nutr Metab (Lond) Research CONTEXT: Body composition may explain partially why non-obese individuals still at the risk of developing non-alcoholic fatty liver disease (NAFLD). The ratio of fat mass to fat-free mass (FM/FFM) has been proposed to assess the combined effect of different body compositions. OBJECTIVE: We aimed to investigate the associations of FM/FFM ratio with the risk of developing NAFLD and fibrosis and to identify the potential mediators according to obesity status. METHODS: This cohort study comprised 3419 adults age ≥ 40 years and free of NAFLD at baseline. Body composition was measured by bioelectrical impedance analysis. NAFLD was ascertained by ultrasonography and fibrosis was assessed by non-invasive score systems. RESULTS: For each 1 standard deviation increment in FM/FFM ratio, the odds ratio for the risk of NAFLD was 1.55 (95% confidence interval [CI] 1.23–1.95) in non-obese men, 1.33 (95% CI 1.08–1.65) in obese men, 1.42 (95% CI 1.44–1.67) in non-obese women, and 1.29 (95% CI 1.12–1.50) in obese women. Similar associations were also found between FM/FFM ratio and NAFLD with fibrosis. Mediation analysis showed that insulin resistance, triglycerides, high-density lipoprotein cholesterol, white blood cells, and total cholesterol mediated the association of FM/FFM ratio with NAFLD risk in specific sex and obesity subgroups. CONCLUSIONS: The FM/FFM ratio significantly associated with the NAFLD and fibrosis risk in both non-obese and obese individuals. Different factors may mediate the association between body composition and NAFLD risk according to different obesity status. BioMed Central 2021-02-19 /pmc/articles/PMC7893940/ /pubmed/33608033 http://dx.doi.org/10.1186/s12986-021-00551-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Dai, Huajie
Xiang, Jiali
Hou, Yanan
Xuan, Liping
Wang, Tiange
Li, Mian
Zhao, Zhiyun
Xu, Yu
Lu, Jieli
Chen, Yuhong
Wang, Weiqing
Ning, Guang
Bi, Yufang
Xu, Min
Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals
title Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals
title_full Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals
title_fullStr Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals
title_full_unstemmed Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals
title_short Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals
title_sort fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893940/
https://www.ncbi.nlm.nih.gov/pubmed/33608033
http://dx.doi.org/10.1186/s12986-021-00551-6
work_keys_str_mv AT daihuajie fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT xiangjiali fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT houyanan fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT xuanliping fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT wangtiange fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT limian fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT zhaozhiyun fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT xuyu fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT lujieli fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT chenyuhong fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT wangweiqing fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT ningguang fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT biyufang fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals
AT xumin fatmasstofatfreemassratioandtheriskofnonalcoholicfattyliverdiseaseandfibrosisinnonobeseandobeseindividuals