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Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences

BACKGROUND: Site-specific C>T DNA base editing has been achieved by recruiting cytidine deaminases to the target C using catalytically impaired Cas proteins; the target C is typically located within 5-nt editing window specified by the guide RNAs. The prototypical cytidine base editor BE3, compri...

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Detalles Bibliográficos
Autores principales:	Yu, Wenxia, Li, Jianan, Huang, Shisheng, Li, Xiangyang, Li, Ping, Li, Guanglei, Liang, Aibin, Chi, Tian, Huang, Xingxu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893952/ https://www.ncbi.nlm.nih.gov/pubmed/33602235 http://dx.doi.org/10.1186/s12915-020-00879-0

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