Cargando…
Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor
L‐type amino acid transporter 1 (LAT1) is highly expressed in various cancers and plays important roles not only in the amino acid uptake necessary for cancer growth but also in cellular signaling. Recent research studies have reported anticancer effects of LAT1 inhibitors and demonstrated their pot...
Autores principales: | Okanishi, Hiroki, Ohgaki, Ryuichi, Okuda, Suguru, Endou, Hitoshi, Kanai, Yoshikatsu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893994/ https://www.ncbi.nlm.nih.gov/pubmed/33264461 http://dx.doi.org/10.1111/cas.14756 |
Ejemplares similares
-
Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells
por: Nishikubo, Kou, et al.
Publicado: (2022) -
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1
por: Okanishi, Hiroki, et al.
Publicado: (2022) -
Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation
por: Quan, Lili, et al.
Publicado: (2020) -
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells
por: Nishikubo, Kou, et al.
Publicado: (2023) -
Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models
por: Shi, Zitong, et al.
Publicado: (2023)