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Multiple mutations within individual oncogenes

Recent studies of the cancer genome have identified numerous patients harboring multiple mutations (MM) within individual oncogenes. These MM (de novo MM) in cis synergistically activate the mutated oncogene and promote tumorigenesis, indicating a positive epistatic interaction between mutations. Th...

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Detalles Bibliográficos
Autores principales:	Saito, Yuki, Koya, Junji, Kataoka, Keisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894016/ https://www.ncbi.nlm.nih.gov/pubmed/33073435 http://dx.doi.org/10.1111/cas.14699

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