In silico identification of available drugs targeting cell surface BiP to disrupt SARS-CoV-2 binding and replication: Drug repurposing approach

AIMS: Cell surface binding immunoglobin protein (csBiP) is predicted to be susceptible to SARS-CoV-2 binding. With a substrate-binding domain (SBD) that binds to polypeptides and a nucleotide-binding domain (NBD) that can initiate extrinsic caspase-dependent apoptosis, csBiP may be a promising thera...

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Detalles Bibliográficos
Autores principales: Zhang, Yiming, Greer, Rory A, Song, Yuwei, Praveen, Hrithik, Song, Yuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894100/
https://www.ncbi.nlm.nih.gov/pubmed/33617948
http://dx.doi.org/10.1016/j.ejps.2021.105771

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