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High‐resolution three‐dimensional chromatin profiling of the Chinese hamster ovary cell genome

Chinese hamster ovary (CHO) cell lines are the pillars of a multibillion‐dollar biopharmaceutical industry producing recombinant therapeutic proteins. The effects of local chromatin organization and epigenetic repression within these cell lines result in unpredictable and unstable transgene expressi...

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Detalles Bibliográficos
Autores principales:	Bevan, Stephen, Schoenfelder, Stefan, Young, Robert J., Zhang, Lin, Andrews, Simon, Fraser, Peter, O'Callaghan, Peter M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894165/ https://www.ncbi.nlm.nih.gov/pubmed/33095445 http://dx.doi.org/10.1002/bit.27607

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