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Dynamics of thymus function and T cell receptor repertoire breadth in health and disease

T cell recognition of unknown antigens relies on the tremendous diversity of the T cell receptor (TCR) repertoire; generation of which can only occur in the thymus. TCR repertoire breadth is thus critical for not only coordinating the adaptive response against pathogens but also for mounting a respo...

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Detalles Bibliográficos
Autores principales: Granadier, David, Iovino, Lorenzo, Kinsella, Sinéad, Dudakov, Jarrod A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894242/
https://www.ncbi.nlm.nih.gov/pubmed/33608819
http://dx.doi.org/10.1007/s00281-021-00840-5