Physiologically‐Based Pharmacokinetic Modeling of the Drug–Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug–drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...

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Detalles Bibliográficos
Autores principales: Callegari, Ernesto, Lin, Jian, Tse, Susanna, Goosen, Theunis C., Sahasrabudhe, Vaishali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894401/
https://www.ncbi.nlm.nih.gov/pubmed/33314761
http://dx.doi.org/10.1002/psp4.12581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894401/
https://www.ncbi.nlm.nih.gov/pubmed/33314761
http://dx.doi.org/10.1002/psp4.12581

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