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A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) outbreak initiated the global coronavirus disease 2019 (COVID‐19) pandemic resulting in 42.9 million confirmed infections and > 1.1 million deaths worldwide as of October 26, 2020. Remdesivir is a broad‐spectrum nucleotide prodrug s...

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Detalles Bibliográficos
Autores principales:	Hanafin, Patrick O., Jermain, Brian, Hickey, Anthony J., Kabanov, Alexander V., Kashuba, Angela DM., Sheahan, Timothy P., Rao, Gauri G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894405/ https://www.ncbi.nlm.nih.gov/pubmed/33296558 http://dx.doi.org/10.1002/psp4.12584

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