PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

Coproporphyrin I (CPI) is an endogenous biomarker of OATP1B activity and associated drug‐drug interactions. In this study, a minimal physiologically‐based pharmacokinetic model was developed to investigate the impact of OATP1B1 genotype (c.521T>C), ethnicity, and sex on CPI pharmacokinetics and i...

Descripción completa

Detalles Bibliográficos
Autores principales: Takita, Hiroyuki, Barnett, Shelby, Zhang, Yueping, Ménochet, Karelle, Shen, Hong, Ogungbenro, Kayode, Galetin, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894406/
https://www.ncbi.nlm.nih.gov/pubmed/33289952
http://dx.doi.org/10.1002/psp4.12582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894406/
https://www.ncbi.nlm.nih.gov/pubmed/33289952
http://dx.doi.org/10.1002/psp4.12582

Ejemplares similares