Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys

ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer’s disease was discontinued due to severe adverse effects (AEs) observed in cynomolgus monkey toxicity studies. The acute nature of AE...

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Detalles Bibliográficos
Autores principales: Loberg, Lise I., Chhaya, Meha, Ibraghimov, Alexander, Tarcsa, Edit, Striebinger, Andreas, Popp, Andreas, Huang, Lili, Oellien, Frank, Barghorn, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894423/
https://www.ncbi.nlm.nih.gov/pubmed/33596779
http://dx.doi.org/10.1080/19420862.2021.1887628

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