Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

RasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in defective T lymphocyte development. RASGRP1‐deficient patients suffer from immune deficiency, and the RASGRP1 gene has been linked to autoimmunity. H...

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Detalles Bibliográficos
Autores principales: Baars, Matthijs J.D., Douma, Thera, Simeonov, Dimitre R., Myers, Darienne R., Kulhanek, Kayla, Banerjee, Saikat, Zwakenberg, Susan, Baltissen, Marijke P., Amini, Mojtaba, de Roock, Sytze, van Wijk, Femke, Vermeulen, Michiel, Marson, Alexander, Roose, Jeroen P., Vercoulen, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Immunodeficiencies and autoimmunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894479/
https://www.ncbi.nlm.nih.gov/pubmed/33065764
http://dx.doi.org/10.1002/eji.201948451

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