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Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo

Herpes simplex viruses, HSV-1 and HSV-2, are highly contagious and cause lifelong, latent infections with recurrent outbreaks of oral and/or genital lesions. No cure exists for HSV-1 or HSV-2 infections, but antiviral medications are commonly used to prevent and treat outbreaks. Resistance to antivi...

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Autores principales: Garber, Anna, Barnard, Lianna, Pickrell, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894602/
https://www.ncbi.nlm.nih.gov/pubmed/33593082
http://dx.doi.org/10.1177/2515690X20978394
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author Garber, Anna
Barnard, Lianna
Pickrell, Chris
author_facet Garber, Anna
Barnard, Lianna
Pickrell, Chris
author_sort Garber, Anna
collection PubMed
description Herpes simplex viruses, HSV-1 and HSV-2, are highly contagious and cause lifelong, latent infections with recurrent outbreaks of oral and/or genital lesions. No cure exists for HSV-1 or HSV-2 infections, but antiviral medications are commonly used to prevent and treat outbreaks. Resistance to antivirals has begun to emerge, placing an importance on finding new and effective therapies for prophylaxis and treatment of HSV outbreaks. Botanicals may be effective HSV therapies as the constituents they contain act through a variety of mechanisms, potentially making the development of antiviral resistance more challenging. A wide variety of plants from different regions in the world have been studied for antiviral activity against HSV-1 and/or HSV-2 and showed efficacy of varying degrees. The purpose of this review is to summarize research conducted on whole plant extracts against HSV-1 and/or HSV-2 in vitro and in vivo. The majority of the research reviewed was conducted in vitro using animal cell lines, and some studies used an animal model design. Also summarized are a limited number of human trials conducted using botanical therapies on HSV lesions.
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spelling pubmed-78946022021-02-26 Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo Garber, Anna Barnard, Lianna Pickrell, Chris J Evid Based Integr Med Topical Review Article Herpes simplex viruses, HSV-1 and HSV-2, are highly contagious and cause lifelong, latent infections with recurrent outbreaks of oral and/or genital lesions. No cure exists for HSV-1 or HSV-2 infections, but antiviral medications are commonly used to prevent and treat outbreaks. Resistance to antivirals has begun to emerge, placing an importance on finding new and effective therapies for prophylaxis and treatment of HSV outbreaks. Botanicals may be effective HSV therapies as the constituents they contain act through a variety of mechanisms, potentially making the development of antiviral resistance more challenging. A wide variety of plants from different regions in the world have been studied for antiviral activity against HSV-1 and/or HSV-2 and showed efficacy of varying degrees. The purpose of this review is to summarize research conducted on whole plant extracts against HSV-1 and/or HSV-2 in vitro and in vivo. The majority of the research reviewed was conducted in vitro using animal cell lines, and some studies used an animal model design. Also summarized are a limited number of human trials conducted using botanical therapies on HSV lesions. SAGE Publications 2021-02-16 /pmc/articles/PMC7894602/ /pubmed/33593082 http://dx.doi.org/10.1177/2515690X20978394 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Topical Review Article
Garber, Anna
Barnard, Lianna
Pickrell, Chris
Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo
title Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo
title_full Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo
title_fullStr Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo
title_full_unstemmed Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo
title_short Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo
title_sort review of whole plant extracts with activity against herpes simplex viruses in vitro and in vivo
topic Topical Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894602/
https://www.ncbi.nlm.nih.gov/pubmed/33593082
http://dx.doi.org/10.1177/2515690X20978394
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