Optimization of Busulfan Dosing Regimen in Pediatric Patients Using a Population Pharmacokinetic Model Incorporating GST Mutations

PURPOSE: The aim of this study was to develop a novel busulfan dosing regimen, based on a population pharmacokinetic (PPK) model in Chinese children, and to achieve better area under the concentration-time curve (AUC) targeting. PATIENTS AND METHODS: We collected busulfan concentration-time samples...

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Detalles Bibliográficos
Autores principales: Yuan, Jinjie, Sun, Ning, Feng, Xinying, He, Huan, Mei, Dong, Zhu, Guanghua, Zhao, Libo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894888/
https://www.ncbi.nlm.nih.gov/pubmed/33623415
http://dx.doi.org/10.2147/PGPM.S289834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894888/
https://www.ncbi.nlm.nih.gov/pubmed/33623415
http://dx.doi.org/10.2147/PGPM.S289834

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