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Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals
Cancer is driven by somatic mutations that result in a cellular fitness advantage. This selective advantage is expected to be counterbalanced by the immune system when these driver mutations simultaneously lead to the generation of neoantigens, novel peptides that are presented at the cancer cell me...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895404/ https://www.ncbi.nlm.nih.gov/pubmed/33556087 http://dx.doi.org/10.1371/journal.pgen.1009368 |