A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection

Cancer cells display high levels of DNA damage and replication stress, vulnerabilities that could be exploited by drugs targeting DNA repair proteins. Human CtIP promotes homology-mediated repair of DNA double-strand breaks (DSBs) and protects stalled replication forks from nucleolytic degradation,...

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Detalles Bibliográficos
Autores principales: Kuster, Anika, Mozaffari, Nour L., Wilkinson, Oliver J., Wojtaszek, Jessica L., Zurfluh, Christina, Przetocka, Sara, Zyla, Dawid, von Aesch, Christine, Dillingham, Mark S., Williams, R. Scott, Sartori, Alessandro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895427/
https://www.ncbi.nlm.nih.gov/pubmed/33608267
http://dx.doi.org/10.1126/sciadv.abc6381

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