Cargando…

Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial

BACKGROUND: Poststroke aphasia (PSA) is a disabling condition that decreases the quality of life, and the duration of the disease harms the quality of life of PSA patients. Acupuncture has been widely employed for PSA. There is some evidence for the immediate treatment efficacy of acupuncture for PS...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiaolin, Gao, Ying, Zhang, Chi, Zhang, Qingsu, Xin, Xiyan, Tan, Zhongjian, Zhang, Binlong, Fan, Ruiwen, Huang, Xing, Xu, Minjie, Shu, Xin, Yan, Heming, Li, Changming, Kong, Qiao, Li, Shuren, Chang, Jingling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895559/
https://www.ncbi.nlm.nih.gov/pubmed/33628323
http://dx.doi.org/10.1155/2021/8880590
_version_ 1783653378291662848
author Li, Xiaolin
Gao, Ying
Zhang, Chi
Zhang, Qingsu
Xin, Xiyan
Tan, Zhongjian
Zhang, Binlong
Fan, Ruiwen
Huang, Xing
Xu, Minjie
Shu, Xin
Yan, Heming
Li, Changming
Kong, Qiao
Li, Shuren
Chang, Jingling
author_facet Li, Xiaolin
Gao, Ying
Zhang, Chi
Zhang, Qingsu
Xin, Xiyan
Tan, Zhongjian
Zhang, Binlong
Fan, Ruiwen
Huang, Xing
Xu, Minjie
Shu, Xin
Yan, Heming
Li, Changming
Kong, Qiao
Li, Shuren
Chang, Jingling
author_sort Li, Xiaolin
collection PubMed
description BACKGROUND: Poststroke aphasia (PSA) is a disabling condition that decreases the quality of life, and the duration of the disease harms the quality of life of PSA patients. Acupuncture has been widely employed for PSA. There is some evidence for the immediate treatment efficacy of acupuncture for PSA; however, long-term results after acupuncture may be poorer. METHODS: This is a multicentre, randomized, blinded, nonacupoint (NA) acupuncture controlled, multimodal neuroimaging clinical trial. A total of 48 subjects with subacute PSA will be randomly assigned to an acupoint group or an NA control group. The acupoint group will receive acupuncture with normal needling at DU20, EX-HN1, HT5, GB39, EX-HN12, EX-HN13, and CV23. The NA control group will receive acupuncture in locations not corresponding to acupuncture points as sham acupoints. Both groups will receive identical speech and language therapy thrice a week for four weeks. The primary outcome will be the change in the aphasia quotient (AQ) score measured by the Western Aphasia Battery (WAB) test during the 12th week after randomization. Participants will be blindly assessed at prerandomization (baseline) and 4 weeks, 12 weeks, and 24 weeks after randomization. The secondary outcomes include the Boston Diagnostic Aphasia Examination (BDAE) score, the Disease Prognosis Scale score for ischaemic stroke, etc. Magnetic resonance imaging (MRI) and electroencephalogram (EEG) will also be performed at 4-time intervals as secondary outcomes. All scores and image evaluations will be taken at the same point as the linguistic evaluation. The multilevel evaluation technique will be used to assess the long-term efficacy of acupuncture therapy. MRI scans and EEG will be used to assess acupuncture-related neuroplasticity changes. Discussion. The results from our trial will help to supply evidence for the long-term acupuncture effects for PSA over a long follow-up period. It will provide valuable information for future studies in the field of PSA treatment. The trial was registered at the Chinese Clinical Trial Registry on 16 March 2020 (ChiCTR2000030879).
format Online
Article
Text
id pubmed-7895559
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-78955592021-02-23 Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial Li, Xiaolin Gao, Ying Zhang, Chi Zhang, Qingsu Xin, Xiyan Tan, Zhongjian Zhang, Binlong Fan, Ruiwen Huang, Xing Xu, Minjie Shu, Xin Yan, Heming Li, Changming Kong, Qiao Li, Shuren Chang, Jingling Evid Based Complement Alternat Med Research Article BACKGROUND: Poststroke aphasia (PSA) is a disabling condition that decreases the quality of life, and the duration of the disease harms the quality of life of PSA patients. Acupuncture has been widely employed for PSA. There is some evidence for the immediate treatment efficacy of acupuncture for PSA; however, long-term results after acupuncture may be poorer. METHODS: This is a multicentre, randomized, blinded, nonacupoint (NA) acupuncture controlled, multimodal neuroimaging clinical trial. A total of 48 subjects with subacute PSA will be randomly assigned to an acupoint group or an NA control group. The acupoint group will receive acupuncture with normal needling at DU20, EX-HN1, HT5, GB39, EX-HN12, EX-HN13, and CV23. The NA control group will receive acupuncture in locations not corresponding to acupuncture points as sham acupoints. Both groups will receive identical speech and language therapy thrice a week for four weeks. The primary outcome will be the change in the aphasia quotient (AQ) score measured by the Western Aphasia Battery (WAB) test during the 12th week after randomization. Participants will be blindly assessed at prerandomization (baseline) and 4 weeks, 12 weeks, and 24 weeks after randomization. The secondary outcomes include the Boston Diagnostic Aphasia Examination (BDAE) score, the Disease Prognosis Scale score for ischaemic stroke, etc. Magnetic resonance imaging (MRI) and electroencephalogram (EEG) will also be performed at 4-time intervals as secondary outcomes. All scores and image evaluations will be taken at the same point as the linguistic evaluation. The multilevel evaluation technique will be used to assess the long-term efficacy of acupuncture therapy. MRI scans and EEG will be used to assess acupuncture-related neuroplasticity changes. Discussion. The results from our trial will help to supply evidence for the long-term acupuncture effects for PSA over a long follow-up period. It will provide valuable information for future studies in the field of PSA treatment. The trial was registered at the Chinese Clinical Trial Registry on 16 March 2020 (ChiCTR2000030879). Hindawi 2021-02-12 /pmc/articles/PMC7895559/ /pubmed/33628323 http://dx.doi.org/10.1155/2021/8880590 Text en Copyright © 2021 Xiaolin Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Xiaolin
Gao, Ying
Zhang, Chi
Zhang, Qingsu
Xin, Xiyan
Tan, Zhongjian
Zhang, Binlong
Fan, Ruiwen
Huang, Xing
Xu, Minjie
Shu, Xin
Yan, Heming
Li, Changming
Kong, Qiao
Li, Shuren
Chang, Jingling
Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial
title Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial
title_full Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial
title_fullStr Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial
title_full_unstemmed Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial
title_short Evaluating the Long-Term Efficacy of Acupuncture Therapy for Subacute Poststroke Aphasia: Study Protocol for a Randomized, Blinded, Controlled, Multicentre Trial
title_sort evaluating the long-term efficacy of acupuncture therapy for subacute poststroke aphasia: study protocol for a randomized, blinded, controlled, multicentre trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895559/
https://www.ncbi.nlm.nih.gov/pubmed/33628323
http://dx.doi.org/10.1155/2021/8880590
work_keys_str_mv AT lixiaolin evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT gaoying evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT zhangchi evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT zhangqingsu evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT xinxiyan evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT tanzhongjian evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT zhangbinlong evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT fanruiwen evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT huangxing evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT xuminjie evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT shuxin evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT yanheming evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT lichangming evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT kongqiao evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT lishuren evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial
AT changjingling evaluatingthelongtermefficacyofacupuncturetherapyforsubacutepoststrokeaphasiastudyprotocolforarandomizedblindedcontrolledmulticentretrial