Cargando…

The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats

Mineral components of dental composites are used in many medical and dental applications, including preventive, restorative, and regenerative dentistry. To evaluate the behavioural alterations induced by nanosized particles of novel dental composites, by means of depressive level and cognitive funct...

Descripción completa

Detalles Bibliográficos
Autores principales: Arsenijevic, Natalija, Selakovic, Dragica, Katanic Stankovic, Jelena S., Mihailovic, Vladimir, Mitrovic, Slobodanka, Milenkovic, Jovana, Milanovic, Pavle, Vasovic, Miroslav, Markovic, Snezana D., Zivanovic, Marko, Grujic, Jelena, Jovicic, Nemanja, Rosic, Gvozden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895592/
https://www.ncbi.nlm.nih.gov/pubmed/33628375
http://dx.doi.org/10.1155/2021/6670135
_version_ 1783653386107748352
author Arsenijevic, Natalija
Selakovic, Dragica
Katanic Stankovic, Jelena S.
Mihailovic, Vladimir
Mitrovic, Slobodanka
Milenkovic, Jovana
Milanovic, Pavle
Vasovic, Miroslav
Markovic, Snezana D.
Zivanovic, Marko
Grujic, Jelena
Jovicic, Nemanja
Rosic, Gvozden
author_facet Arsenijevic, Natalija
Selakovic, Dragica
Katanic Stankovic, Jelena S.
Mihailovic, Vladimir
Mitrovic, Slobodanka
Milenkovic, Jovana
Milanovic, Pavle
Vasovic, Miroslav
Markovic, Snezana D.
Zivanovic, Marko
Grujic, Jelena
Jovicic, Nemanja
Rosic, Gvozden
author_sort Arsenijevic, Natalija
collection PubMed
description Mineral components of dental composites are used in many medical and dental applications, including preventive, restorative, and regenerative dentistry. To evaluate the behavioural alterations induced by nanosized particles of novel dental composites, by means of depressive level and cognitive functions, experimental groups of rats were chronically administered with nanosized hydroxyapatite (HA), tricalcium phosphate (TCP), and amorphous calcium phosphate (ACP) with or without simultaneous application of Filipendula ulmaria L. (FU) methanolic extract. The significant prodepressant action was observed in groups solely treated with HA and ACP. Besides, prolonged treatment with ACP also resulted in a significant decline in cognitive functions estimated in the novel object recognition test. The adverse impact of calcium phosphates on estimated behavioural functions was accompanied by increased oxidative damage and apoptotic markers in the prefrontal cortex, as well as diminished specific neurotrophin (BDNF) and gabaergic expression. The results of our investigation showed that simultaneous antioxidant supplementation with FU extract prevented calcium phosphate-induced behavioural disturbances, as well as prooxidative and apoptotic actions, with the simultaneous restoration of BDNF and GABA-A receptors in the prefrontal cortex. These findings suggest that FU may be useful in the prevention of prodepressant impact and cognitive decline as early as the manifestation of calcium phosphate-induced neurotoxicity.
format Online
Article
Text
id pubmed-7895592
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-78955922021-02-23 The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats Arsenijevic, Natalija Selakovic, Dragica Katanic Stankovic, Jelena S. Mihailovic, Vladimir Mitrovic, Slobodanka Milenkovic, Jovana Milanovic, Pavle Vasovic, Miroslav Markovic, Snezana D. Zivanovic, Marko Grujic, Jelena Jovicic, Nemanja Rosic, Gvozden Oxid Med Cell Longev Research Article Mineral components of dental composites are used in many medical and dental applications, including preventive, restorative, and regenerative dentistry. To evaluate the behavioural alterations induced by nanosized particles of novel dental composites, by means of depressive level and cognitive functions, experimental groups of rats were chronically administered with nanosized hydroxyapatite (HA), tricalcium phosphate (TCP), and amorphous calcium phosphate (ACP) with or without simultaneous application of Filipendula ulmaria L. (FU) methanolic extract. The significant prodepressant action was observed in groups solely treated with HA and ACP. Besides, prolonged treatment with ACP also resulted in a significant decline in cognitive functions estimated in the novel object recognition test. The adverse impact of calcium phosphates on estimated behavioural functions was accompanied by increased oxidative damage and apoptotic markers in the prefrontal cortex, as well as diminished specific neurotrophin (BDNF) and gabaergic expression. The results of our investigation showed that simultaneous antioxidant supplementation with FU extract prevented calcium phosphate-induced behavioural disturbances, as well as prooxidative and apoptotic actions, with the simultaneous restoration of BDNF and GABA-A receptors in the prefrontal cortex. These findings suggest that FU may be useful in the prevention of prodepressant impact and cognitive decline as early as the manifestation of calcium phosphate-induced neurotoxicity. Hindawi 2021-02-10 /pmc/articles/PMC7895592/ /pubmed/33628375 http://dx.doi.org/10.1155/2021/6670135 Text en Copyright © 2021 Natalija Arsenijevic et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Arsenijevic, Natalija
Selakovic, Dragica
Katanic Stankovic, Jelena S.
Mihailovic, Vladimir
Mitrovic, Slobodanka
Milenkovic, Jovana
Milanovic, Pavle
Vasovic, Miroslav
Markovic, Snezana D.
Zivanovic, Marko
Grujic, Jelena
Jovicic, Nemanja
Rosic, Gvozden
The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats
title The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats
title_full The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats
title_fullStr The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats
title_full_unstemmed The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats
title_short The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats
title_sort beneficial role of filipendula ulmaria extract in prevention of prodepressant effect and cognitive impairment induced by nanoparticles of calcium phosphates in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895592/
https://www.ncbi.nlm.nih.gov/pubmed/33628375
http://dx.doi.org/10.1155/2021/6670135
work_keys_str_mv AT arsenijevicnatalija thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT selakovicdragica thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT katanicstankovicjelenas thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT mihailovicvladimir thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT mitrovicslobodanka thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT milenkovicjovana thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT milanovicpavle thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT vasovicmiroslav thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT markovicsnezanad thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT zivanovicmarko thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT grujicjelena thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT jovicicnemanja thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT rosicgvozden thebeneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT arsenijevicnatalija beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT selakovicdragica beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT katanicstankovicjelenas beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT mihailovicvladimir beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT mitrovicslobodanka beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT milenkovicjovana beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT milanovicpavle beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT vasovicmiroslav beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT markovicsnezanad beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT zivanovicmarko beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT grujicjelena beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT jovicicnemanja beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats
AT rosicgvozden beneficialroleoffilipendulaulmariaextractinpreventionofprodepressanteffectandcognitiveimpairmentinducedbynanoparticlesofcalciumphosphatesinrats