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Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence

Isoflavone is a phytoestrogen found in different types of food that can act as endocrine disrupters leading to testicular dysfunction. Currently, fragmented data on the action of this compound in the testicles make it difficult to assess its effects to define a safe dose. Thus, we systematically rev...

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Autores principales: Lozi, Amanda Alves, Pinto da Matta, Sérgio Luis, Sarandy, Mariáurea Matias, Silveira Alves de Melo, Fabiana Cristina, Araujo, Diane Costa, Novaes, Rômulo Dias, Gonçalves, Reggiani Vilela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895610/
https://www.ncbi.nlm.nih.gov/pubmed/33628321
http://dx.doi.org/10.1155/2021/8853172
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author Lozi, Amanda Alves
Pinto da Matta, Sérgio Luis
Sarandy, Mariáurea Matias
Silveira Alves de Melo, Fabiana Cristina
Araujo, Diane Costa
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
author_facet Lozi, Amanda Alves
Pinto da Matta, Sérgio Luis
Sarandy, Mariáurea Matias
Silveira Alves de Melo, Fabiana Cristina
Araujo, Diane Costa
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
author_sort Lozi, Amanda Alves
collection PubMed
description Isoflavone is a phytoestrogen found in different types of food that can act as endocrine disrupters leading to testicular dysfunction. Currently, fragmented data on the action of this compound in the testicles make it difficult to assess its effects to define a safe dose. Thus, we systematically reviewed the preclinical evidence of the impact of isoflavone on testicular function. We also determined which form (aglycones or glycosylated) was the most used, which allowed us to understand the main biological processes involved in testicular function after isoflavone exposure. This systematic review was carried out according to the PRISMA guidelines using a structured search on the biomedical databases MEDLINE (PubMed), Scopus, and Web of Science, recovering and analyzing 22 original studies. The bias analysis and the quality of the studies were assessed by the criteria described in the risk of bias tool developed by SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation). The aglycones and glycosylated isoflavones proved to be harmful to the reproductive health, and the glycosylates at doses of 50, 100, 146, 200, 300, 500, and 600 mg/kg, in addition to 190 and 1000 mg/L, appear to be even more harmful. The main testicular pathologies resulting from the use of isoflavones are associated with Leydig cells resulting from changes in molecular functions and cellular components. The most used isoflavone to evaluate testicular changes was the genistein/daidzein conjugate. The consumption of high doses of isoflavones promotes changes in the functioning of Leydig cells, inducing testicular changes and leading to infertility in murine models.
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spelling pubmed-78956102021-02-23 Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence Lozi, Amanda Alves Pinto da Matta, Sérgio Luis Sarandy, Mariáurea Matias Silveira Alves de Melo, Fabiana Cristina Araujo, Diane Costa Novaes, Rômulo Dias Gonçalves, Reggiani Vilela Evid Based Complement Alternat Med Review Article Isoflavone is a phytoestrogen found in different types of food that can act as endocrine disrupters leading to testicular dysfunction. Currently, fragmented data on the action of this compound in the testicles make it difficult to assess its effects to define a safe dose. Thus, we systematically reviewed the preclinical evidence of the impact of isoflavone on testicular function. We also determined which form (aglycones or glycosylated) was the most used, which allowed us to understand the main biological processes involved in testicular function after isoflavone exposure. This systematic review was carried out according to the PRISMA guidelines using a structured search on the biomedical databases MEDLINE (PubMed), Scopus, and Web of Science, recovering and analyzing 22 original studies. The bias analysis and the quality of the studies were assessed by the criteria described in the risk of bias tool developed by SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation). The aglycones and glycosylated isoflavones proved to be harmful to the reproductive health, and the glycosylates at doses of 50, 100, 146, 200, 300, 500, and 600 mg/kg, in addition to 190 and 1000 mg/L, appear to be even more harmful. The main testicular pathologies resulting from the use of isoflavones are associated with Leydig cells resulting from changes in molecular functions and cellular components. The most used isoflavone to evaluate testicular changes was the genistein/daidzein conjugate. The consumption of high doses of isoflavones promotes changes in the functioning of Leydig cells, inducing testicular changes and leading to infertility in murine models. Hindawi 2021-02-12 /pmc/articles/PMC7895610/ /pubmed/33628321 http://dx.doi.org/10.1155/2021/8853172 Text en Copyright © 2021 Amanda Alves Lozi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lozi, Amanda Alves
Pinto da Matta, Sérgio Luis
Sarandy, Mariáurea Matias
Silveira Alves de Melo, Fabiana Cristina
Araujo, Diane Costa
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence
title Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence
title_full Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence
title_fullStr Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence
title_full_unstemmed Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence
title_short Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence
title_sort relevance of the isoflavone absorption and testicular function: a systematic review of preclinical evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895610/
https://www.ncbi.nlm.nih.gov/pubmed/33628321
http://dx.doi.org/10.1155/2021/8853172
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