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Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designe...

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Autores principales: Jia, Zhanrong, Lv, Xuanhan, Hou, Yue, Wang, Kefeng, Ren, Fuzeng, Xu, Dingguo, Wang, Qun, Fan, Kelong, Xie, Chaoming, Lu, Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895678/
https://www.ncbi.nlm.nih.gov/pubmed/33665500
http://dx.doi.org/10.1016/j.bioactmat.2021.01.033
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author Jia, Zhanrong
Lv, Xuanhan
Hou, Yue
Wang, Kefeng
Ren, Fuzeng
Xu, Dingguo
Wang, Qun
Fan, Kelong
Xie, Chaoming
Lu, Xiong
author_facet Jia, Zhanrong
Lv, Xuanhan
Hou, Yue
Wang, Kefeng
Ren, Fuzeng
Xu, Dingguo
Wang, Qun
Fan, Kelong
Xie, Chaoming
Lu, Xiong
author_sort Jia, Zhanrong
collection PubMed
description Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis.
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spelling pubmed-78956782021-03-03 Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics Jia, Zhanrong Lv, Xuanhan Hou, Yue Wang, Kefeng Ren, Fuzeng Xu, Dingguo Wang, Qun Fan, Kelong Xie, Chaoming Lu, Xiong Bioact Mater Article Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis. KeAi Publishing 2021-02-13 /pmc/articles/PMC7895678/ /pubmed/33665500 http://dx.doi.org/10.1016/j.bioactmat.2021.01.033 Text en © 2021 [The Author/The Authors] http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Jia, Zhanrong
Lv, Xuanhan
Hou, Yue
Wang, Kefeng
Ren, Fuzeng
Xu, Dingguo
Wang, Qun
Fan, Kelong
Xie, Chaoming
Lu, Xiong
Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
title Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
title_full Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
title_fullStr Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
title_full_unstemmed Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
title_short Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
title_sort mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895678/
https://www.ncbi.nlm.nih.gov/pubmed/33665500
http://dx.doi.org/10.1016/j.bioactmat.2021.01.033
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