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An unusual cause of fever and jaundice

A 52 year old previously healthy woman from Mumbai presented with fever and jaundice of 10 days duration. At admission, she was jaundiced with tachycardia, tachypnea, hypoxia, hypotension, conjunctival congestion and mild erythematous flush over the skin. She had very high WBC counts and CRP's...

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Autores principales: Varyani, Umesh, Singhal, Tanu, Sheth, Sharad, Shetty, Kiran, Harshe, Pradnya, Shah, Sweta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Association of Medical Microbiologists. Published by Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895698/
https://www.ncbi.nlm.nih.gov/pubmed/33617927
http://dx.doi.org/10.1016/j.ijmmb.2021.02.001
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author Varyani, Umesh
Singhal, Tanu
Sheth, Sharad
Shetty, Kiran
Harshe, Pradnya
Shah, Sweta
author_facet Varyani, Umesh
Singhal, Tanu
Sheth, Sharad
Shetty, Kiran
Harshe, Pradnya
Shah, Sweta
author_sort Varyani, Umesh
collection PubMed
description A 52 year old previously healthy woman from Mumbai presented with fever and jaundice of 10 days duration. At admission, she was jaundiced with tachycardia, tachypnea, hypoxia, hypotension, conjunctival congestion and mild erythematous flush over the skin. She had very high WBC counts and CRP's with direct hyperbilirubinemia and azotemia. Investigations for infectious causes of fever were negative. RT-PCR for SARS-CoV-2 in the nasopharynx was negative. However her SARS-CoV-2 antibodies were reactive. She also had echocardiographic and biochemical evidence of cardiac dysfunction. The diagnosis of Multisystem inflammatory syndrome–Adult (MIS-A) was thus established. She rapidly improved with intravenous immunoglobulin (2 gm/kg) and high dose steroids.
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spelling pubmed-78956982021-02-22 An unusual cause of fever and jaundice Varyani, Umesh Singhal, Tanu Sheth, Sharad Shetty, Kiran Harshe, Pradnya Shah, Sweta Indian J Med Microbiol Original Research Article A 52 year old previously healthy woman from Mumbai presented with fever and jaundice of 10 days duration. At admission, she was jaundiced with tachycardia, tachypnea, hypoxia, hypotension, conjunctival congestion and mild erythematous flush over the skin. She had very high WBC counts and CRP's with direct hyperbilirubinemia and azotemia. Investigations for infectious causes of fever were negative. RT-PCR for SARS-CoV-2 in the nasopharynx was negative. However her SARS-CoV-2 antibodies were reactive. She also had echocardiographic and biochemical evidence of cardiac dysfunction. The diagnosis of Multisystem inflammatory syndrome–Adult (MIS-A) was thus established. She rapidly improved with intravenous immunoglobulin (2 gm/kg) and high dose steroids. Indian Association of Medical Microbiologists. Published by Elsevier B.V. 2021-07 2021-02-25 /pmc/articles/PMC7895698/ /pubmed/33617927 http://dx.doi.org/10.1016/j.ijmmb.2021.02.001 Text en © 2021 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Research Article
Varyani, Umesh
Singhal, Tanu
Sheth, Sharad
Shetty, Kiran
Harshe, Pradnya
Shah, Sweta
An unusual cause of fever and jaundice
title An unusual cause of fever and jaundice
title_full An unusual cause of fever and jaundice
title_fullStr An unusual cause of fever and jaundice
title_full_unstemmed An unusual cause of fever and jaundice
title_short An unusual cause of fever and jaundice
title_sort unusual cause of fever and jaundice
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895698/
https://www.ncbi.nlm.nih.gov/pubmed/33617927
http://dx.doi.org/10.1016/j.ijmmb.2021.02.001
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