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An unusual cause of fever and jaundice
A 52 year old previously healthy woman from Mumbai presented with fever and jaundice of 10 days duration. At admission, she was jaundiced with tachycardia, tachypnea, hypoxia, hypotension, conjunctival congestion and mild erythematous flush over the skin. She had very high WBC counts and CRP's...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Indian Association of Medical Microbiologists. Published by Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895698/ https://www.ncbi.nlm.nih.gov/pubmed/33617927 http://dx.doi.org/10.1016/j.ijmmb.2021.02.001 |
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author | Varyani, Umesh Singhal, Tanu Sheth, Sharad Shetty, Kiran Harshe, Pradnya Shah, Sweta |
author_facet | Varyani, Umesh Singhal, Tanu Sheth, Sharad Shetty, Kiran Harshe, Pradnya Shah, Sweta |
author_sort | Varyani, Umesh |
collection | PubMed |
description | A 52 year old previously healthy woman from Mumbai presented with fever and jaundice of 10 days duration. At admission, she was jaundiced with tachycardia, tachypnea, hypoxia, hypotension, conjunctival congestion and mild erythematous flush over the skin. She had very high WBC counts and CRP's with direct hyperbilirubinemia and azotemia. Investigations for infectious causes of fever were negative. RT-PCR for SARS-CoV-2 in the nasopharynx was negative. However her SARS-CoV-2 antibodies were reactive. She also had echocardiographic and biochemical evidence of cardiac dysfunction. The diagnosis of Multisystem inflammatory syndrome–Adult (MIS-A) was thus established. She rapidly improved with intravenous immunoglobulin (2 gm/kg) and high dose steroids. |
format | Online Article Text |
id | pubmed-7895698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Indian Association of Medical Microbiologists. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78956982021-02-22 An unusual cause of fever and jaundice Varyani, Umesh Singhal, Tanu Sheth, Sharad Shetty, Kiran Harshe, Pradnya Shah, Sweta Indian J Med Microbiol Original Research Article A 52 year old previously healthy woman from Mumbai presented with fever and jaundice of 10 days duration. At admission, she was jaundiced with tachycardia, tachypnea, hypoxia, hypotension, conjunctival congestion and mild erythematous flush over the skin. She had very high WBC counts and CRP's with direct hyperbilirubinemia and azotemia. Investigations for infectious causes of fever were negative. RT-PCR for SARS-CoV-2 in the nasopharynx was negative. However her SARS-CoV-2 antibodies were reactive. She also had echocardiographic and biochemical evidence of cardiac dysfunction. The diagnosis of Multisystem inflammatory syndrome–Adult (MIS-A) was thus established. She rapidly improved with intravenous immunoglobulin (2 gm/kg) and high dose steroids. Indian Association of Medical Microbiologists. Published by Elsevier B.V. 2021-07 2021-02-25 /pmc/articles/PMC7895698/ /pubmed/33617927 http://dx.doi.org/10.1016/j.ijmmb.2021.02.001 Text en © 2021 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Research Article Varyani, Umesh Singhal, Tanu Sheth, Sharad Shetty, Kiran Harshe, Pradnya Shah, Sweta An unusual cause of fever and jaundice |
title | An unusual cause of fever and jaundice |
title_full | An unusual cause of fever and jaundice |
title_fullStr | An unusual cause of fever and jaundice |
title_full_unstemmed | An unusual cause of fever and jaundice |
title_short | An unusual cause of fever and jaundice |
title_sort | unusual cause of fever and jaundice |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895698/ https://www.ncbi.nlm.nih.gov/pubmed/33617927 http://dx.doi.org/10.1016/j.ijmmb.2021.02.001 |
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