Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation

The SCF(SKP2) ubiquitin ligase relieves G1 checkpoint control of CDK-cyclin complexes by promoting p27KIP1 degradation. We describe reconstitution of stable complexes containing SKP1-SKP2 and CDK1-cyclin B or CDK2-cyclin A/E, mediated by the CDK regulatory subunit CKS1. We further show that a direct...

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Detalles Bibliográficos
Autores principales: Salamina, Marco, Montefiore, Bailey C., Liu, Mengxi, Wood, Daniel J., Heath, Richard, Ault, James R., Wang, Lan-Zhen, Korolchuk, Svitlana, Baslé, Arnaud, Pastok, Martyna W., Reeks, Judith, Tatum, Natalie J., Sobott, Frank, Arold, Stefan T., Pagano, Michele, Noble, Martin E.M., Endicott, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895821/
https://www.ncbi.nlm.nih.gov/pubmed/33422522
http://dx.doi.org/10.1016/j.jmb.2020.166795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895821/
https://www.ncbi.nlm.nih.gov/pubmed/33422522
http://dx.doi.org/10.1016/j.jmb.2020.166795

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