E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3

Ubiquitination is one of the most prevalent protein posttranslational modifications. Here, we show that E3 ligase Nedd4l positively regulates antiviral immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3. Deficiency of Nedd4l significantly impairs type I interferon and proinflammatory...

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Detalles Bibliográficos
Autores principales: Gao, Peng, Ma, Xianwei, Yuan, Ming, Yi, Yulan, Liu, Guoke, Wen, Mingyue, Jiang, Wei, Ji, Ruihua, Zhu, Lingxi, Tang, Zhen, Yu, Qingzhuo, Xu, Jing, Yang, Rui, Xia, Sheng, Yang, Mingjin, Pan, Jianping, Yuan, Hongbin, An, Huazhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895832/
https://www.ncbi.nlm.nih.gov/pubmed/33608556
http://dx.doi.org/10.1038/s41467-021-21456-1

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