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SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling
Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth. However, for a significant portion of human cancer, how Hippo signaling is perturbed remains unknown. To answer this question, we performed a genome-wide screening for genes t...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895894/ https://www.ncbi.nlm.nih.gov/pubmed/32661924 http://dx.doi.org/10.1007/s13238-020-00742-6 |