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Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
Post-zygotic mutations that generate tissue mosaicism are increasingly associated with severe congenital defects, including those arising from failed neural tube closure. Here we report that neural fold elevation during mouse spinal neurulation is vulnerable to deletion of the VANGL planar cell pola...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895924/ https://www.ncbi.nlm.nih.gov/pubmed/33608529 http://dx.doi.org/10.1038/s41467-021-21372-4 |