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Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome

An unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report that the Streptococcus species improved the skin struc...

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Autores principales: Kim, Gihyeon, Kim, Misun, Kim, Minji, Park, Changho, Yoon, Youngmin, Lim, Doo-Hyeon, Yeo, Hyeonju, Kang, Seunghyun, Lee, Yeong-Geun, Beak, Nam-In, Lee, Jongsung, Kim, Sujeong, Kwon, Jee Young, Choi, Won Woo, Lee, Charles, Yoon, Kyoung Wan, Park, Hansoo, Lee, Dong-Geol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895926/
https://www.ncbi.nlm.nih.gov/pubmed/33608630
http://dx.doi.org/10.1038/s42003-020-01619-4
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author Kim, Gihyeon
Kim, Misun
Kim, Minji
Park, Changho
Yoon, Youngmin
Lim, Doo-Hyeon
Yeo, Hyeonju
Kang, Seunghyun
Lee, Yeong-Geun
Beak, Nam-In
Lee, Jongsung
Kim, Sujeong
Kwon, Jee Young
Choi, Won Woo
Lee, Charles
Yoon, Kyoung Wan
Park, Hansoo
Lee, Dong-Geol
author_facet Kim, Gihyeon
Kim, Misun
Kim, Minji
Park, Changho
Yoon, Youngmin
Lim, Doo-Hyeon
Yeo, Hyeonju
Kang, Seunghyun
Lee, Yeong-Geun
Beak, Nam-In
Lee, Jongsung
Kim, Sujeong
Kwon, Jee Young
Choi, Won Woo
Lee, Charles
Yoon, Kyoung Wan
Park, Hansoo
Lee, Dong-Geol
author_sort Kim, Gihyeon
collection PubMed
description An unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report that the Streptococcus species improved the skin structure and barrier function, thereby contributing to anti-aging. Metagenomic analyses showed the abundance of Streptococcus in younger individuals or those having more elastic skin. Particularly, we isolated Streptococcus pneumoniae, Streptococcus infantis, and Streptococcus thermophilus from face of young individuals. Treatment with secretions of S. pneumoniae and S. infantis induced the expression of genes associated with the formation of skin structure and the skin barrier function in human skin cells. The application of culture supernatant including Streptococcal secretions on human skin showed marked improvements on skin phenotypes such as elasticity, hydration, and desquamation. Gene Ontology analysis revealed overlaps in spermidine biosynthetic and glycogen biosynthetic processes. Streptococcus-secreted spermidine contributed to the recovery of skin structure and barrier function through the upregulation of collagen and lipid synthesis in aged cells. Overall, our data suggest the role of skin microbiome into anti-aging and clinical applications.
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spelling pubmed-78959262021-03-03 Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome Kim, Gihyeon Kim, Misun Kim, Minji Park, Changho Yoon, Youngmin Lim, Doo-Hyeon Yeo, Hyeonju Kang, Seunghyun Lee, Yeong-Geun Beak, Nam-In Lee, Jongsung Kim, Sujeong Kwon, Jee Young Choi, Won Woo Lee, Charles Yoon, Kyoung Wan Park, Hansoo Lee, Dong-Geol Commun Biol Article An unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report that the Streptococcus species improved the skin structure and barrier function, thereby contributing to anti-aging. Metagenomic analyses showed the abundance of Streptococcus in younger individuals or those having more elastic skin. Particularly, we isolated Streptococcus pneumoniae, Streptococcus infantis, and Streptococcus thermophilus from face of young individuals. Treatment with secretions of S. pneumoniae and S. infantis induced the expression of genes associated with the formation of skin structure and the skin barrier function in human skin cells. The application of culture supernatant including Streptococcal secretions on human skin showed marked improvements on skin phenotypes such as elasticity, hydration, and desquamation. Gene Ontology analysis revealed overlaps in spermidine biosynthetic and glycogen biosynthetic processes. Streptococcus-secreted spermidine contributed to the recovery of skin structure and barrier function through the upregulation of collagen and lipid synthesis in aged cells. Overall, our data suggest the role of skin microbiome into anti-aging and clinical applications. Nature Publishing Group UK 2021-02-19 /pmc/articles/PMC7895926/ /pubmed/33608630 http://dx.doi.org/10.1038/s42003-020-01619-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Gihyeon
Kim, Misun
Kim, Minji
Park, Changho
Yoon, Youngmin
Lim, Doo-Hyeon
Yeo, Hyeonju
Kang, Seunghyun
Lee, Yeong-Geun
Beak, Nam-In
Lee, Jongsung
Kim, Sujeong
Kwon, Jee Young
Choi, Won Woo
Lee, Charles
Yoon, Kyoung Wan
Park, Hansoo
Lee, Dong-Geol
Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome
title Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome
title_full Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome
title_fullStr Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome
title_full_unstemmed Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome
title_short Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome
title_sort spermidine-induced recovery of human dermal structure and barrier function by skin microbiome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895926/
https://www.ncbi.nlm.nih.gov/pubmed/33608630
http://dx.doi.org/10.1038/s42003-020-01619-4
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