KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

The first step of RAF activation involves binding to active RAS, resulting in the recruitment of RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, we present crystal structures of wild-type and oncogenic mutants of KRAS complexed with the RAS-binding domain (RBD...

Descripción completa

Detalles Bibliográficos
Autores principales: Tran, Timothy H., Chan, Albert H., Young, Lucy C., Bindu, Lakshman, Neale, Chris, Messing, Simon, Dharmaiah, Srisathiyanarayanan, Taylor, Troy, Denson, John-Paul, Esposito, Dominic, Nissley, Dwight V., Stephen, Andrew G., McCormick, Frank, Simanshu, Dhirendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895934/
https://www.ncbi.nlm.nih.gov/pubmed/33608534
http://dx.doi.org/10.1038/s41467-021-21422-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895934/
https://www.ncbi.nlm.nih.gov/pubmed/33608534
http://dx.doi.org/10.1038/s41467-021-21422-x

Ejemplares similares