Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

A balanced t(1;11) translocation that directly disrupts DISC1 is linked to schizophrenia and affective disorders. We previously showed that a mutant mouse, named Der1, recapitulates the effect of the translocation upon DISC1 expression. Here, RNAseq analysis of Der1 mouse brain tissue found enrichme...

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Detalles Bibliográficos
Autores principales: Bonneau, Marion, Sullivan, Shane T. O’, Gonzalez-Lozano, Miguel A., Baxter, Paul, Gautier, Phillippe, Marchisella, Elena, Hardingham, Neil R., Chesters, Robert A., Torrance, Helen, Howard, David M., Jansen, Maurits A., McMillan, Melanie, Singh, Yasmin, Didier, Michel, Koopmans, Frank, Semple, Colin A., McIntosh, Andrew M., Volkmer, Hansjürgen, Loos, Maarten, Fox, Kevin, Hardingham, Giles E., Vernon, Anthony C., Porteous, David J., Smit, August B., Price, David J., Kirsty Millar, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895946/
https://www.ncbi.nlm.nih.gov/pubmed/33608504
http://dx.doi.org/10.1038/s41398-021-01256-3

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