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Calculating metalation in cells reveals CobW acquires Co(II) for vitamin B(12) biosynthesis while related proteins prefer Zn(II)

Protein metal-occupancy (metalation) in vivo has been elusive. To address this challenge, the available free energies of metals have recently been determined from the responses of metal sensors. Here, we use these free energy values to develop a metalation-calculator which accounts for inter-metal c...

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Detalles Bibliográficos
Autores principales:	Young, Tessa R., Martini, Maria Alessandra, Foster, Andrew W., Glasfeld, Arthur, Osman, Deenah, Morton, Richard J., Deery, Evelyne, Warren, Martin J., Robinson, Nigel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895991/ https://www.ncbi.nlm.nih.gov/pubmed/33608553 http://dx.doi.org/10.1038/s41467-021-21479-8

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