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LSD alters dynamic integration and segregation in the human brain

Investigating changes in brain function induced by mind-altering substances such as LSD is a powerful method for interrogating and understanding how mind interfaces with brain, by connecting novel psychological phenomena with their neurobiological correlates. LSD is known to increase measures of bra...

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Autores principales: Luppi, Andrea I., Carhart-Harris, Robin L., Roseman, Leor, Pappas, Ioannis, Menon, David K., Stamatakis, Emmanuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896102/
https://www.ncbi.nlm.nih.gov/pubmed/33338615
http://dx.doi.org/10.1016/j.neuroimage.2020.117653
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author Luppi, Andrea I.
Carhart-Harris, Robin L.
Roseman, Leor
Pappas, Ioannis
Menon, David K.
Stamatakis, Emmanuel A.
author_facet Luppi, Andrea I.
Carhart-Harris, Robin L.
Roseman, Leor
Pappas, Ioannis
Menon, David K.
Stamatakis, Emmanuel A.
author_sort Luppi, Andrea I.
collection PubMed
description Investigating changes in brain function induced by mind-altering substances such as LSD is a powerful method for interrogating and understanding how mind interfaces with brain, by connecting novel psychological phenomena with their neurobiological correlates. LSD is known to increase measures of brain complexity, potentially reflecting a neurobiological correlate of the especially rich phenomenological content of psychedelic-induced experiences. Yet although the subjective stream of consciousness is a constant ebb and flow, no studies to date have investigated how LSD influences the dynamics of functional connectivity in the human brain. Focusing on the two fundamental network properties of integration and segregation, here we combined graph theory and dynamic functional connectivity from resting-state functional MRI to examine time-resolved effects of LSD on brain networks properties and subjective experiences. Our main finding is that the effects of LSD on brain function and subjective experience are non-uniform in time: LSD makes globally segregated sub-states of dynamic functional connectivity more complex, and weakens the relationship between functional and anatomical connectivity. On a regional level, LSD reduces functional connectivity of the anterior medial prefrontal cortex, specifically during states of high segregation. Time-specific effects were correlated with different aspects of subjective experiences; in particular, ego dissolution was predicted by increased small-world organisation during a state of high global integration. These results reveal a more nuanced, temporally-specific picture of altered brain connectivity and complexity under psychedelics than has previously been reported.
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spelling pubmed-78961022021-03-02 LSD alters dynamic integration and segregation in the human brain Luppi, Andrea I. Carhart-Harris, Robin L. Roseman, Leor Pappas, Ioannis Menon, David K. Stamatakis, Emmanuel A. Neuroimage Article Investigating changes in brain function induced by mind-altering substances such as LSD is a powerful method for interrogating and understanding how mind interfaces with brain, by connecting novel psychological phenomena with their neurobiological correlates. LSD is known to increase measures of brain complexity, potentially reflecting a neurobiological correlate of the especially rich phenomenological content of psychedelic-induced experiences. Yet although the subjective stream of consciousness is a constant ebb and flow, no studies to date have investigated how LSD influences the dynamics of functional connectivity in the human brain. Focusing on the two fundamental network properties of integration and segregation, here we combined graph theory and dynamic functional connectivity from resting-state functional MRI to examine time-resolved effects of LSD on brain networks properties and subjective experiences. Our main finding is that the effects of LSD on brain function and subjective experience are non-uniform in time: LSD makes globally segregated sub-states of dynamic functional connectivity more complex, and weakens the relationship between functional and anatomical connectivity. On a regional level, LSD reduces functional connectivity of the anterior medial prefrontal cortex, specifically during states of high segregation. Time-specific effects were correlated with different aspects of subjective experiences; in particular, ego dissolution was predicted by increased small-world organisation during a state of high global integration. These results reveal a more nuanced, temporally-specific picture of altered brain connectivity and complexity under psychedelics than has previously been reported. Academic Press 2021-02-15 /pmc/articles/PMC7896102/ /pubmed/33338615 http://dx.doi.org/10.1016/j.neuroimage.2020.117653 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luppi, Andrea I.
Carhart-Harris, Robin L.
Roseman, Leor
Pappas, Ioannis
Menon, David K.
Stamatakis, Emmanuel A.
LSD alters dynamic integration and segregation in the human brain
title LSD alters dynamic integration and segregation in the human brain
title_full LSD alters dynamic integration and segregation in the human brain
title_fullStr LSD alters dynamic integration and segregation in the human brain
title_full_unstemmed LSD alters dynamic integration and segregation in the human brain
title_short LSD alters dynamic integration and segregation in the human brain
title_sort lsd alters dynamic integration and segregation in the human brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896102/
https://www.ncbi.nlm.nih.gov/pubmed/33338615
http://dx.doi.org/10.1016/j.neuroimage.2020.117653
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