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Analysis of lysosomal hydrolase trafficking and activity in human iPSC-derived neuronal models

Lysosomes are critical for maintaining protein homeostasis and cellular metabolism. Lysosomal dysfunction and disrupted protein trafficking contribute to cell death in neurodegenerative disorders, including Parkinson's disease and dementia. We describe three complementary protocols—the use of p...

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Detalles Bibliográficos
Autores principales:	Cuddy, Leah K., Mazzulli, Joseph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896187/ https://www.ncbi.nlm.nih.gov/pubmed/33659904 http://dx.doi.org/10.1016/j.xpro.2021.100340

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