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Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells

We present a unifying theory to explain cancer recurrence, therapeutic resistance, and lethality. The basis of this theory is the formation of simultaneously polyploid and aneuploid cancer cells, polyaneuploid cancer cells (PACCs), that avoid the toxic effects of systemic therapy by entering a state...

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Detalles Bibliográficos
Autores principales:	Pienta, K. J., Hammarlund, E. U., Brown, J. S., Amend, S. R., Axelrod, R. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896294/ https://www.ncbi.nlm.nih.gov/pubmed/33504594 http://dx.doi.org/10.1073/pnas.2020838118

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