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SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice
P27, a cell cycle inhibitor, is also able to drive repression of Sox2. This interaction plays a crucial role during development of p27(−/−) pituitary tumors because loss of one copy of Sox2 impairs tumorigenesis [H. Li et al., Cell Stem Cell 11, 845–852 (2012)]. However, SOX2 is expressed in both en...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896314/ https://www.ncbi.nlm.nih.gov/pubmed/33574062 http://dx.doi.org/10.1073/pnas.2017115118 |