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Silymarin modulates catabolic cytokine expression through Sirt1 and SOX9 in human articular chondrocytes

BACKGROUND: Silymarin (SMN), a polyphenolic flavonoid, is involved in multiple bioactive functions including anti-inflammation. Pretreatment with SMN demonstrated chondroprotection against tumour necrosis factor-alpha (TNF-α) stimulation in a chondrocyte cell line. However, pre- and posttreatment wi...

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Detalles Bibliográficos
Autores principales:	Wu, Wen-Tien, Chen, Yi-Ru, Lu, Dai-Hua, Senatov, Fedor Svyatoslavovich, Yang, Kai-Chiang, Wang, Chen-Chie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896383/ https://www.ncbi.nlm.nih.gov/pubmed/33610183 http://dx.doi.org/10.1186/s13018-021-02305-9

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