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Breast tuberculosis: a case series

BACKGROUND AND AIM: Breast tuberculosis is a rare disease, even in endemic areas. The diagnosis can be challenging, as it can mimic breast cancer. We aim to report our experience and discuss diagnoses and management modalities. RESULTS: We encountered twelve cases of breast tuberculosis in our insti...

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Autores principales: Ghalleb, M., Seghaier, S., Adouni, O., Bouaziz, H., Bouida, A., Hassouna, J. Ben, Chargui, R., Rahal, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896393/
https://www.ncbi.nlm.nih.gov/pubmed/33608057
http://dx.doi.org/10.1186/s13256-020-02646-9
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author Ghalleb, M.
Seghaier, S.
Adouni, O.
Bouaziz, H.
Bouida, A.
Hassouna, J. Ben
Chargui, R.
Rahal, K.
author_facet Ghalleb, M.
Seghaier, S.
Adouni, O.
Bouaziz, H.
Bouida, A.
Hassouna, J. Ben
Chargui, R.
Rahal, K.
author_sort Ghalleb, M.
collection PubMed
description BACKGROUND AND AIM: Breast tuberculosis is a rare disease, even in endemic areas. The diagnosis can be challenging, as it can mimic breast cancer. We aim to report our experience and discuss diagnoses and management modalities. RESULTS: We encountered twelve cases of breast tuberculosis in our institution from 2004 to 2019. The average age of our Caucasian North African patients was 42 years old (22–63). The classic presentation was a breast lump found in half of the cases. On physical examination, we suspected breast carcinoma in seven patients. The average size of the tumors was 39 mm (15–80 mm). Nine patients had a mammogram. In five cases, there was a suspicious breast mass mimicking a malignant tumor with an average size of 33 mm (25–60 mm). A ultrasonography was performed in 6 cases and revealed a suspicious ill-circumscribed nodule in four patients with an average size of 37.5 mm (10–60 mm). Five patients had a lumpectomy, and seven women underwent drainage of the abscess and the biopsy of its hull. The association of epithelioid cell granulomas and caseous necrosis was mandatory for the histological diagnosis of tuberculosis. All of them had an antitubercular therapy. The median period of follow-up was of 43 months (3–156 months). One patient presented with a recurrent abscess of the breast. CONCLUSION: Our study found that clinical examination and radiological imaging were not specific. Positive cultures for Koch bacillus or histological confirmation are mandatory for the diagnosis. A meta-analysis of the existing cases is needed.
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spelling pubmed-78963932021-02-22 Breast tuberculosis: a case series Ghalleb, M. Seghaier, S. Adouni, O. Bouaziz, H. Bouida, A. Hassouna, J. Ben Chargui, R. Rahal, K. J Med Case Rep Case Report BACKGROUND AND AIM: Breast tuberculosis is a rare disease, even in endemic areas. The diagnosis can be challenging, as it can mimic breast cancer. We aim to report our experience and discuss diagnoses and management modalities. RESULTS: We encountered twelve cases of breast tuberculosis in our institution from 2004 to 2019. The average age of our Caucasian North African patients was 42 years old (22–63). The classic presentation was a breast lump found in half of the cases. On physical examination, we suspected breast carcinoma in seven patients. The average size of the tumors was 39 mm (15–80 mm). Nine patients had a mammogram. In five cases, there was a suspicious breast mass mimicking a malignant tumor with an average size of 33 mm (25–60 mm). A ultrasonography was performed in 6 cases and revealed a suspicious ill-circumscribed nodule in four patients with an average size of 37.5 mm (10–60 mm). Five patients had a lumpectomy, and seven women underwent drainage of the abscess and the biopsy of its hull. The association of epithelioid cell granulomas and caseous necrosis was mandatory for the histological diagnosis of tuberculosis. All of them had an antitubercular therapy. The median period of follow-up was of 43 months (3–156 months). One patient presented with a recurrent abscess of the breast. CONCLUSION: Our study found that clinical examination and radiological imaging were not specific. Positive cultures for Koch bacillus or histological confirmation are mandatory for the diagnosis. A meta-analysis of the existing cases is needed. BioMed Central 2021-02-20 /pmc/articles/PMC7896393/ /pubmed/33608057 http://dx.doi.org/10.1186/s13256-020-02646-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Ghalleb, M.
Seghaier, S.
Adouni, O.
Bouaziz, H.
Bouida, A.
Hassouna, J. Ben
Chargui, R.
Rahal, K.
Breast tuberculosis: a case series
title Breast tuberculosis: a case series
title_full Breast tuberculosis: a case series
title_fullStr Breast tuberculosis: a case series
title_full_unstemmed Breast tuberculosis: a case series
title_short Breast tuberculosis: a case series
title_sort breast tuberculosis: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896393/
https://www.ncbi.nlm.nih.gov/pubmed/33608057
http://dx.doi.org/10.1186/s13256-020-02646-9
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AT charguir breasttuberculosisacaseseries
AT rahalk breasttuberculosisacaseseries